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Figure 1


Fig. 1. Laminin {alpha}5 is greatly reduced in the small intestine of postnatal KO/Tg mice. (A) Schematic diagram of the Mr5 transgene. (B,C) Frozen sections of small intestine from newborn Het/Tg (B) and KO/Tg (C) mice. Immunostaining for laminin {alpha}5 revealed similar levels in the epithelial BM. (D-I) Representative pictures of laminin-{alpha}5 staining in the proximal (PSI), middle (MSI) and distal (DSI) small intestine of adult mice. (D,F,H) Laminin {alpha}5 was abundantly deposited in the subepithelial BM of control villi (denoted by arrowhead), with almost none in the crypts. (E,G,I) Laminin {alpha}5 was greatly reduced in the villus BM of KO/Tg mice but was detectable in mesenchymal structures within villi (arrows) and in intestinal smooth muscle (asterisks) of both Het/Tg and KO/Tg mice. Bars, 100 µm.