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Figure 4


Fig. 4. Star is required for suppression of Gl1 by Dhc alleles. Epistasis tests were carried out by examining different mutant combinations using SEM. Representative examples of (A) the Gl1 eye, and (B) the Gl1 eye enhanced by S1, are shown to allow comparisons. (C) Su(Gl)77, a mutation in the Dhc locus, partially suppresses the Gl1 dominant eye phenotype. Dhc8-1 similarly suppresses the Gl1 rough eye (not shown). (D) The mutation in Star overcomes the suppression effect of the Dhc allele Su(Gl)77, and results in an enhanced Gl1 phenotype. The same result (not shown) is seen with Dhc8-1 in the presence of Gl1 and S1. (E) Su(Gl)77 in combination with Dhc8-1 completely suppresses the Gl1 eye phenotype. (F) Despite the presence of two Dhc mutations that suppress Gl1, S1 still shows enhancement of the Gl1 rough eye. Genotypes shown: (A) +/+; Gl1/+, (B) S1/+; Gl1/+, (C) Su(Gl)77 Gl1/+, (D) S1/+; Su(Gl)77 Gl1/+, (E) +/+; Su(Gl)77 Gl1/Dhc8-1, (F) S1/+; Su(Gl)77 Gl1/Dhc8-1.