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Figure 4


Fig. 4. Effect of cathepsin X on T lymphocyte migration. Data are expressed as the mean ± s.d. of triplicate wells. The percentage of migration obtained for wild-type cells was normalised to 1. (A) Cathepsin-X-overexpressing Jurkat T lymphocytes migration on uncoated polycarbonate membranes. (B) Cathepsin-X-overexpressing Jurkat T lymphocyte migration on ICAM1 coated membranes. 2F12, cathepsin-X-neutralising mAb (1 µM); AMS36, epoxysuccinyl-based specific inhibitor of cathepsin X (2 µM).