Fig. 7. Effect of cathepsin X on T lymphocyte Matrigel invasion. The percentage of invasion obtained for wild-type cells was normalised to 1. Cathepsin X transfection increased Jurkat T lymphocyte invasion through Matrigel 8.3-fold compared with wild-type cells. The invasion of cathepsin-X-overexpressing Jurkat T lymphocytes was inhibited by 29% by 2F12 anti-cathepsin-X-neutralising mAb and by 33% by cathepsin-X-specific inhibitor AMS36 (Fig. 7). Data are expressed the mean ± s.d. of triplicate wells.