Fig. 8. Roles of putative cell-death mediators in lipotoxic cell death of S. pombe. (A,B) Viability of the indicated TKO cells in rich medium. (C,D) Viability of the indicated TKO cells in minimal medium.
pca1,
rad9,
pck1 and
bzz1 TKO cells exhibited attenuated cell death as compared with DKO cells only in minimal medium. Deletion of pck2+ or apg6+, however, had no effect in both media. Values shown are means with s.e.m. from independent experiments (n
3). +/*P<0.05; ++/**P<0.005; +++/***P<0.0005.