Fig. 1. β-catenin interacts with TrkA in PC12 6/15 cells, and with TrkB and TrkC in hippocampal neurons. (A) Control (Myc) or β-catenin immunoprecipitation from PC12 6/15 cells starved or stimulated with NGF (100 ng/ml) for different times (as indicated) shows that TrkA (detected with anti-pan-Trk antibodies: 140-kDa and 110-kDa forms) co-immunoprecipitates with β-catenin, independent of its phosphorylation state. (B) Control (GFP) or pan-Trk immunoprecipitation from hippocampal neurons untreated or treated with BDNF or NT-3 (50 ng/ml; 5 minutes) shows that TrkB and TrkC co-immunoprecipitate with β-catenin.