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Figure 1


Fig. 1. Unitary synapses in response to presynaptic pair-spikes (50 msecond intervals) express facilitation, depression and parallel patterns. (A) Paired presynaptic spikes (bottom trace) evoke a facilitation pattern of uEPSCs (top trace, R2>R1) at a unitary synapse (W-081200). (B) uEPSC amplitude is larger in R2 than R1 at each unitary synapse (P<0.05, n=12/39). (C) Spikes (bottom trace) evoke a depression pattern of uEPSCs (top trace, R2<R1) at a unitary synapse (W-070800). (D) uEPSC at R1 is larger than at R2 at unitary synapses (P<0.05, n=20/39). (E) Paired-spikes (bottom trace) evoke a parallel pattern of uEPSCs (top trace, R2=R1) at a unitary synapse (W-071203). (F) uEPSC at R2 equals that at R1 at each unitary synapse (P>0.05, n=7/39). In B, D and F, each pair of symbols denotes the averaged R1 and R2 from a unitary synapse. (G) R2-R1 and R1 in all 39 synapses examined are negatively correlated (r2=0.7).