Fig. 7. The influence of the integrated currents from excitatory unitary synapses on spike programming at cortical GABA neurons. The rows from top to bottom are the integrated current pulses, spikes and spike timing; and columns A-C show spike patterns superimposed from 40 traces under three conditions. (A) Spike firing and timing evoked by a pulse similar to that in Fig. 6A (control). (B) Spike firing and timing evoked by a pulse that is simulated so that postsynaptic CaM converts inactive synapses into active ones. Fluctuating synaptic patterns were converted to a uniform pattern with an enhanced uEPSC1. (C) Spike firing and timing evoked by pulses that are simulated when presynaptic inputs are more synchronously activated (^*, inter-input intervals changes from 0.6-1.6 to 0.5-1.0 mseconds). Such changes raise the amplitude of the integrated inputs, which improves spike capacity and timing precision.