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Figure 4


Fig. 4. Activation of cAMP-response element (CRE) in the CCND1 promoter by VRK1. (A) The luciferase activity of cells transfected with kinase-dead (KD) or wild-type (WT) VRK1 was measured. The results represent mean ± s.d. from experiments performed triplicate. (B,C) ChIP assay measuring the CREB-P (B) and ATF2 (C) binding to CRE in the CCND1 promoter of HeLa cells transfected with either KD-VRK1 or WT-VRK1.