Fig. 2. Memory for objects is impaired during aging in both SynI^–/– and SynII^–/– mice. The object-recognition performance of WT, SynI^–/– and SynII^–/– mice was analyzed in young (A), adult (B) and aged (C) mice (eight to ten mice per group). The two test sessions were carried out 3 and 24 hours after the presentation of the first pairs of objects and the percentage of time spent on the new object was plotted as means ± s.e.m. Statistical analysis was performed by using one-way ANOVA. Young: F(2,27)_{Time 0hrs} = 0.91, not significant; F(2,27)_{Time 3hrs} = 0.41, not significant; F(2,27)_{Time 24hrs} = 0.94, not significant. Adult: F(2,35)_{Time 0hrs} = 1.15, not significant; F(2,35)_{Time 3hrs} = 1.88, not significant; F(2,35)_{Time 24hrs} = 5.38, P<0.01. Aged: F(2,30)_{Time 0hrs} = 2.79, not significant; F(2,30)_{Time 3hrs} = 0.94, not significant; F(2,30)_{Time 24hrs} =16.93, P<0.001. This was followed by the Bonferroni's multiple comparison test (^*P<0.05, ^**P<0.01 and ^***P<0.001 for either SynI^–/– or SynII^–/– vs WT).