JCS -- Chan et al. 121 (19): 3218 Figure IG6

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Fig. 6. Deneddylation activity of DEN1. Neddylated proteins in DEN1^null larval lysates (lane 2) could be depleted by the co-incubated GST-DEN1 (lane 4), displaying a pattern largely identical to that detected in the wild-type lysates (lane 1). When the DEN1^null lysates were treated with purified GST (lane 3) or GST-DEN1CA (lane 5), the neddylation pattern is similar to that without any treatment (lane 2).