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Figure 7


Fig. 7. Model for DEN1 activity in vivo. DEN1 functions in the processing the C terminus of Nedd8 precursor, generating mature Nedd8 with exposed di-Gly motif that is available for neddylation. The Nedd8 moiety on cullin proteins is deconjugated by the CSN. However, we propose that conjugated Nedd8 on other non-cullin proteins is deconjugated by DEN1.