Fig. 2. Activities that might be influenced by asymmetric cell division in lymphocytes. Lymphocytes (pale green) divide while attached to a spatial cue (grey) that dictates the axis of division. In each case, the polarity network (grey circles) and perhaps direct interactions with the polarising cue, regulate the asymmetric distribution of cell fate determinants (coloured circles), such that they are segregated differently into the two daughter cells of naive CD8⁺ or CD4⁺ T cells responding to APCs (A,B), and perhaps in thymocytes responding to thymic epithelial cells (TECs) (C).