Fig. 3. (A) Domain structure and covalent modifications of the human SLC12 co-transporters NKCC1, NKCC2 and NCC. (B) Sequence alignment of the N-terminal region of NCC, NKCC1 and NKCC2, which is regulated by phosphorylation. Identical residues are highlighted in black and similar residues are in grey. Numbering above symbols indicates residue number on human NCC. h, human; m, mouse; s, shark.