Fig. 2. Effect of activation of M on their glycolytic metabolism. The rate of glucose uptake (A), rate of lactate release (B) and LDH activity in cell homogenates (C) were determined in untreated cells or in those activated with IFN and LPS. Co-administration of SEITU partly prevented the increase in all three parameters of glycolytic metabolism that was observed in activated cells. Mean±s.d., n=3-5. There were significant differences (P<0.05, one way ANOVA, Tukey's post hoc test) in the glucose uptake rates, lactate release rates and LDH activities between the IFN + LPS + SEITU-treated group and all the other groups at each sampling time, except at time zero.