Fig. 1. Comparison of CblA to metazoan Cbl protein family members. The top part of the figure is the output from a BLAST search, showing the predicted RING finger, EF-hand and SH2 domains. It also shows the positions of simple repeat sequence (blue) and the positions of four alpha helical segments (black arrowheads) and their length, as predicted by the program JPRED (Cuff and Barton, 2000). The lower three panels show alignments of CblA with Cbl family EF-hand domains, with a Cbl type and two orthodox SH2 domains and with Cbl family RING fingers. The red lines over the SH2 domains indicate the universally conserved R residue and the divergent adjacent residues that initially confused identification of the Cbl SH2 domain (Meng et al., 1999).