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Figure 2


Fig. 2. Proposed functions of CD34-family proteins: promoting and blocking adhesion. (A) L-selectin expressed on naive lymphocytes recognizes HEV-specific glycosylation motifs on CD34-family members and mediates cell adhesion. (B) The bulky, negatively charged extracellular domains of CD34 family members block cell adhesion by charge repulsion and steric hindrance; this prevents interaction of integrins with their ligands.