Fig. 6. Contributions of formins to spindle orientation revealed by genetic analysis. The impact of mutating formin genes on actin cable organisation (red lines) Bud6p accumulation (green circles), actin-mediated transport (black arrowheads) and spindle position (green bar) is depicted schematically. For each mutant, an integrative overview is provided, including (A) sites for Bud6p-dependent MT capture, (B) preferred target sites for Kar9p-mediated delivery, and the differential contributions of Bud6p and Kar9p as deduced from the respective mutant phenotypes (C,D) in otherwise wild-type cells as well as in combination with formin mutations (Miller et al., 1999; Lee et al., 1999; Segal et al., 2000a, Yeh et al., 2000; Huisman et al., 2004). For simplicity, the additive effects of mutating BUD6 or KAR9 are not depicted in the diagrams.