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Figure 8


Fig. 8. HDAC6-deficient cells have defects in aggresome formation. (A) Verification of HDAC6 knockout by western blot. (B) Quantification of the percentage of cells with ubiquitin-containing aggresomes, n≥100. (C) Quantitative evaluation of the size of ubiquitin-containing aggresomes, n≥50. (D) Quantitative evaluation of the size of FAT10-containing aggresomes, n≥10. Error bars represent the standard error of the mean (s.e.m.); statistical analysis was carried out using Student's t-test.