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Figure 3


Fig. 3. Effect of genetic inactivation of p110{alpha} or p110{delta} on basal and CSF1-induced morphological changes in BMMs. (A) CSF1-starved or CSF1-stimulated cells were stained for F-actin. Scale bar: 30 µm. (B-D) Measurement of elongation ratio (ratio of the longest to the shortest cell axes, B), total area of adhesion (C) and ruffling (D). The results shown are mean ± s.e.m. of >=180 cells from each population. ***P<0.0001; **P<0.05. Comparison labelled 1 was with unstimulated WT; 2 with unstimulated {alpha}D933A/WT; and 3 with unstimulated {delta}D910A/WT cells.