Fig. 1. Schematic of the human TNRC6A gene products GW182 and TNGW1. (A) GW182 has been reported to be a 182-kDa protein product of 1709 amino acids and containing three GW-rich regions, a QN-rich region and a classical RNA recognition motif (RRM). TNGW1 is the novel 210-kDa GW182 isoform with an extra N-terminal 253-amino-acid polypeptide containing a stretch of glutamine-repeat (Q-repeat) that is translated from the CAG TNR. (B) TNRC6A resides in human chromosome 16p11.2. The 5' end corresponding to the mRNA of these two isoforms separates 60 kb on chromosome 16. (C) The TNR Q-repeat domain was encoded from the fifth exon and the corresponding nucleotide and amino acid sequences are shown in this panel. (D) Alignment of N-terminal TNGW1 sequences from mouse, rat and human using ClustalW. The result shows sequence conservation within these three species with some degree of diversity (yellow) in the TNR Q-repeat region.