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Figure 9


Fig. 9. A model showing how EPHA2 overexpression promotes destabilization of adherens junctions. Overexpression of EPHA2 increases the recruitment of LMW-PTP and Src kinase. Increased LMW-PTP phosphatase activity dephosphorylates p190 RhoGAP and inhibits p190 RhoGAP activity. Decreased p190 RhoGAP activity in turn upregulates activated Rho-GTP levels. Rho signaling through ROCK destabilizes the adherens junction.