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Figure 1


Fig. 1. Palmitoylated RAS hypervariable regions (HVRs). Alignment of palmitoylated RAS HVR sequences reveals regions of strong homology between isoforms that are conserved between species (A). Patches B1 and B2 containing basic (+) and hydrophobic ({phi}) residues are conserved together with a precisely located central pair of acidic (–) residues. K(B)-RAS is shown for reference (B). (C) GFP-tagged HVR mutants used for the analysis of membrane targeting.