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Figure 2


Fig. 2. The linker domain influences the targeting of palmitoylated RAS. Singly palmitoylated N- and K(A)-RAS show stronger cell-surface localisation when the linker domain is present (HVR-N/HVR-KA versus tN/tKA). Dually palmitoylated H-RAS does not require an upstream linker sequence for stable cell-surface localisation (tH versus HVR-H). Bars, 10 µm.