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Figure 2


Fig. 2. Expression and regulation of CD147. (A) CD147 mRNA levels in monocytic THP1 cells are upregulated by stimulation with MDP, TNF-{alpha} plus IFN-{gamma} and infection with L. monocytogenes. (B) THP1 monocytes were stimulated for 24 hours with different agents (thick line) or left untreated (thin line). Cell surface expression of CD147 protein was detected by FACS. Irrelevant antibody was used as specificity control (gray curve). A variety of proinflammatory stimuli (MDP, LPS, TNF-{alpha}/IFN-{gamma}) lead to an increased expression of CD147. Note that TNF-{alpha} alone showed only a minor effect.