Fig. 1. Schematic view of the domain structure of LRP1 [adapted from Li et al. (Li et al., 2000) and Springer (Springer, 1998)] and PrP^C, for which the flexible N- and structured C-terminal domains, and GPI anchor, are indicated; grey lines represent the surface membrane. LRP1 domains and the site of furin cleavage are indicated; Roman numerals indicate the four repeats of the ligand-binding complement-like domains; endocytic motifs are indicated in the cytoplasmic domain. LRP1, with >4500 amino acids, is more than 20 times larger than PrP^C (208 amino acids).