Fig. 3. RNAi depletion of IKAP results in migration defects in rat cerebellar granule neurons that can be rescued by full-length but not FD-IKAP. (A) Migration of cerebellar granule neurons transiently transfected with designated IKBKAP (M2) or scr siRNA oligonucleotide and/or IKBKAP plasmids was quantified and normalized to control levels (means ± s.d.; n=4; ^**P<0.01; ^***P<0.001). (B) Viability of neurons expressing designated IKBKAP or scr siRNA and/or IKBKAP plasmids (means ± s.d.; n=4).