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Figure 3


Fig. 3. Unique heterochromatin body visualized by TEM corresponds to the Barr body. (A,B) Serial sections (200 nm) show one and only one heterochromatin body in a WI-38 nucleus with the size, shape and characteristic chromatin ultrastructure of the Barr body (comparable to LM images). (A) Two equatorial sections, 8 and 11 (S8, S11), of the whole nucleus. See supplementary material Fig. S1 for the complete set of serial sections. (B) Details of the heterochromatin body of the above nucleus, sections 5-12 (S5-S12). (C) H3-3mK27 (rabbit antibody) immunogold labeling decorating the Xi heterochromatin periphery. Arrowheads and arrows point to the Barr body; Nu, nucleolus.