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Figure 11


Fig. 11. TPA promotes EC tube morphogenesis through PKC. ECs were suspended in collagen matrices for 24 hours in the absence and presence of PKC inhibitors GF109203X (2.5 µM), Ro-32-0432 (5 µM), Go6983 (5 µM) or Go6976 (5 µM). (A) Quantification of the mean number of EC lumens per HPF±s.d. (n=2). *, P<0.08 compared with the TPA control. (B) Tracing of the mean EC lumenal area (Metamorph software)±s.d (n=2). *, P<0.05 compared with control TPA.