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Figure 4


Fig. 4. Identification of Cdc42 and Rac1 effectors regulating EC tubular morphogenesis and invasion. (A-C) ECs were treated with the indicated siRNAs and were suspended within collagen matrices (A) or on the surface of collagen matrices containing either S1P (B) or SDF-1{alpha} (C). Quantification occurred at either 48 hours (A,C) or 24 hours (B). The data are shown as the mean number of EC lumens per HPF (A) or invading ECs per HPF (B,C) ±s.d. (n=5). *, P<0.01 compared with luciferase control.