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Figure 6


Fig. 6. Deficiency of C/EBPβ decreases KA-induced expression of LCN2 and histidine decarboxylase. (A,B) C/EBPβ+/+ and C/EBPβ–/– adult mice were injected with vehicle (V) or KA and sacrificed 24 hours post-injection. Coronal sections (30 µm) were stained with antibodies against (A) LCN2 or (B) histidine decarboxylase. C/EBPβ–/– mice exhibited lower levels of LCN2 and histidine decarboxylase after KA injection, as compared with littermate controls. Representative results from three independent experiments are shown. Scale bars, 25 µm. SR, stratum radiatum; GL, granular layer; Hil, hilus.