Fig. 4. Ultrastructure of the endocytic compartment in Sktl-deficient oocytes. (A) Electron micrograph of a stage 9 wt egg chamber, showing a representative region of the lateral cortex. Note the presence of: CCP, clathrin-coated pits (black arrowheads in A-C); EEVs, early endocytic vesicles (double arrowheads in A-C); T, tubular intermediates (black arrows in A-C); Y3, condensed yolk granules. (B,C) Electron micrographs of a stage 9 sktl^2.3 GLC egg chamber, showing two regions of the lateral cortex in this context. (B) Note the presence of CCPs on long abnormal PM invaginations (red arrowhead) and the presence of abnormal yolk-containing profiles apparently not connected with the PM (red arrows). (C) Note the presence of large accumulations of yolk proteins at the oocyte PM (green arrowhead); the presence of yolk-containing profiles apparently not connected with the PM are very rare. oo, oocyte; fc, follicle cells; Y1, forming yolk granule. Scale bars: 500 nm.