Fig. 6. L-type Ca²⁺ channels mediate DCV exocytosis in hippocampal neurons. Release probabilities in the neuronal soma in response to 90 mM K⁺ were determined after treatment with the indicated Ca²⁺-channel inhibitors. Verapamil at 100 µM (specific for L-type Ca²⁺ channels) completely blocked evoked DCV exocytosis [total number of analyzed vesicles (n)=803], whereas 10 µM -conotoxin MVIIC (N- and Q-type specific, n=734) and 200 nM -agatoxin TK (P-type specific, n=712) were without effect (P>0.5 by t-test).