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Journal of Cell Science, Vol 10, 495-513, Copyright © 1972 by Company of Biologists

Submitted on September 27, 1971

Premature Chromosome Condensation: a Mechanism for the Elimination of Chromosomes in Virus-Fused Cells

P. N. RAO 1 and R. T. JOHNSON 2

1 Department of Biophysics and Genetics and the Eleanor Roosevelt Institute for Cancer Research, University of Colorado Medical Center, Denver, Colorado, U.S.A., and Department of Zoology, University of Cambridge, Cambridge, England; Department of Developmental Therapeutics, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston, Texas, U.S.A.
2 Department of Biophysics and Genetics and the Eleanor Roosevelt Institute for Cancer Research, University of Colorado Medical Center, Denver, Colorado, U.S.A., and Department of Zoology, University of Cambridge, Cambridge, England

The fate of prematurely condensed chromosomes (PCC) that are induced following fusion between a mitotic and an interphase cell was studied in the homokaryons of HeLa and 2 glycine-requiring mutants of Chinese hamster ovary cells. The data indicate: (1) the prematurely condensed chromosomes are often incorporated into daughter nuclei of the fused cells and hence they are functionally retained by the progeny; (2) in general, the only viable products of fusion between mitotic and interphase cells are those where PCC has been induced; (3) fusion between mitotic and S-phase cells leads to the most rapid loss of chromosomes, while the homophasic fusions tend to produce more stable hybrids with regard to their chromosome number.

Submitted on September 27, 1971




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© The Company of Biologists Ltd 1972