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Journal of Cell Science, Vol 101, Issue 2 323-332, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

Down-regulation of scatter factor in MRC 5 fibroblasts by epithelial-derived cells. A model for scatter factor modulation

T Kamalati, B Thirunavukarasu, A Wallace, N Holder, R Brooks, T Nakamura, M Stoker, E Gherardi and L Buluwela
Biomedical Sciences Division, King's College London, Strand, UK.

Scatter factor/hepatocyte growth factor (SF/HGF) is a multifunctional cytokine produced by embryonic fibroblasts and other mesenchymal cells that affects the growth and/or the movement of certain epithelia. Here we report that expression of scatter factor activity by MRC 5 cells, a strain of normal human embryonic lung fibroblasts, is greatly reduced as a result of co-culture of these cells with SVK14, an SV40-transformed human keratinocyte cell line. Using a cDNA probe to the beta chain of human HGF, we have found that the fall in SF activity in MRC 5/SVK14 co-cultures is accompanied by the loss of SF/HGF transcripts. As the inhibition of SF activity coincides with the disappearance of SF/HGF transcript, we conclude that inhibition of the SF activity expressed by MRC 5 cells by co-culture with SVK14 involves transcriptional regulation.


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© The Company of Biologists Ltd 1992