|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 103, Issue 2 589-597, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
J Dahlstrand, LB Zimmerman, RD McKay and U Lendahl
Department of Molecular Genetics, Karolinska Institute, Stockholm, Sweden.
Multipotential stem cells in the neural tube give rise to the different neuronal cell types found in the brain. Abrupt changes in intermediate filament gene expression accompany this transition out of the precursor state: transcription of the intermediate filament nestin is replaced by that of the neurofilaments. In order to identify human neural precursor cells, and to learn more about the evolution of the intermediate filaments expressed in the central nervous system, we have isolated the human nestin gene. Despite considerable divergence between the human and rat nestin genes, in particular in the repetitive parts of the carboxy-terminal region, the positions of the introns are perfectly conserved. Two of the three intron positions are also shared by the neurofilaments, but not by other classes of intermediate filaments. This implies that nestin and the neurofilaments had a common ancestor after branching off from the other classes of intermediate filaments, and that nestin separated from the neurofilament branch before the different neurofilament genes diverged. The characterization of human nestin also facilitates the identification of human multipotential neural precursor cells. This will be of importance for central nervous system (CNS) tumor diagnosis and transplant-based clinical approaches to human neurodegenerative diseases.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  Y.-H. Chou, W.-L. Kuo, M. R. Rosner, W.-J. Tang, and R. D. Goldman Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme FASEB J, November 1, 2009; 23(11): 3734 - 3742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Parry, K Savage, C Marchio, and J S Reis-Filho Nestin is expressed in basal-like and triple negative breast cancers J. Clin. Pathol., September 1, 2008; 61(9): 1045 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mangiola, G. Lama, C. Giannitelli, P. De Bonis, C. Anile, L. Lauriola, G. La Torre, G. Sabatino, G. Maira, M. Jhanwar-Uniyal, et al. Stem Cell Marker Nestin and c-Jun NH2-Terminal Kinases in Tumor and Peritumor Areas of Glioblastoma Multiforme: Possible Prognostic Implications Clin. Cancer Res., December 1, 2007; 13(23): 6970 - 6977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Li, P. Cherukuri, N. Li, V. Cowling, M. Spinella, M. Cole, A. K. Godwin, W. Wells, and J. DiRenzo Nestin Is Expressed in the Basal/Myoepithelial Layer of the Mammary Gland and Is a Selective Marker of Basal Epithelial Breast Tumors Cancer Res., January 15, 2007; 67(2): 501 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Lee, K. W. McCool, F. E. Murdoch, and M. K. Fritsch Dynamic Changes in Histone H3 Phosphoacetylation during Early Embryonic Stem Cell Differentiation Are Directly Mediated by Mitogen- and Stress-activated Protein Kinase 1 via Activation of MAPK Pathways J. Biol. Chem., July 28, 2006; 281(30): 21162 - 21172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Ehrmann, Z Kolar, and J Mokry Nestin as a diagnostic and prognostic marker: immunohistochemical analysis of its expression in different tumours J. Clin. Pathol., February 1, 2005; 58(2): 222 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Thomas, C. A. Messam, B. A. Spengler, J. L. Biedler, and R. A. Ross Nestin Is a Potential Mediator of Malignancy in Human Neuroblastoma Cells J. Biol. Chem., July 2, 2004; 279(27): 27994 - 27999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-H. Chou, S. Khuon, H. Herrmann, and R. D. Goldman Nestin Promotes the Phosphorylation-dependent Disassembly of Vimentin Intermediate Filaments During Mitosis Mol. Biol. Cell, April 1, 2003; 14(4): 1468 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Almqvist, R. Mah, U. Lendahl, B. Jacobsson, and G. Hendson Immunohistochemical Detection of Nestin in Pediatric Brain Tumors J. Histochem. Cytochem., February 1, 2002; 50(2): 147 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zulewski, E. J. Abraham, M. J. Gerlach, P. B. Daniel, W. Moritz, B. Müller, M. Vallejo, M. K. Thomas, and J. F. Habener Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes Diabetes, March 1, 2001; 50(3): 521 - 533. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Tsujimura, C. Makiishi-Shimobayashi, J. Lundkvist, U. Lendahl, K. Nakasho, A. Sugihara, T. Iwasaki, M. Mano, N. Yamada, K. Yamashita, et al. Expression of the Intermediate Filament Nestin in Gastrointestinal Stromal Tumors and Interstitial Cells of Cajal Am. J. Pathol., March 1, 2001; 158(3): 817 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. GOLDMAN, Y.-H. CHOU, V. PRAHLAD, and M. YOON Intermediate filaments: dynamic processes regulating their assembly, motility, and interactions with other cytoskeletal systems FASEB J, December 1, 1999; 13(9002): 261S - 265S. [Full Text] [PDF]
|
|
|
|
|
|
P. M. Steinert, Y.-H. Chou, V. Prahlad, D. A. D. Parry, L. N. Marekov, K. C. Wu, S.-I. Jang, and R. D. Goldman A High Molecular Weight Intermediate Filament-associated Protein in BHK-21 Cells Is Nestin, a Type VI Intermediate Filament Protein. LIMITED CO-ASSEMBLY IN VITRO TO FORM HETEROPOLYMERS WITH TYPE III VIMENTIN AND TYPE IV alpha -INTERNEXIN J. Biol. Chem., April 2, 1999; 274(14): 9881 - 9890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vaittinen, R. Lukka, C. Sahlgren, J. Rantanen, T. Hurme, U. Lendahl, J. E. Eriksson, and H. Kalimo Specific and Innervation-Regulated Expression of the Intermediate Filament Protein Nestin at Neuromuscular and Myotendinous Junctions in Skeletal Muscle Am. J. Pathol., February 1, 1999; 154(2): 591 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sultana, R. Zhou, M. S. Sadagopan, and O. Skalli Effects of Growth Factors and Basement Membrane Proteins on the Phenotype of U-373 MG Glioblastoma Cells as Determined by the Expression of Intermediate Filament Proteins Am. J. Pathol., October 1, 1998; 153(4): 1157 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. B. Crino, J. Q. Trojanowski, M. A. Dichter, and J. Eberwine Embryonic neuronal markers in tuberous sclerosis: Single-cell molecular pathology PNAS, November 26, 1996; 93(24): 14152 - 14157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Sejersen and U Lendahl Transient expression of the intermediate filament nestin during skeletal muscle development J. Cell Sci., January 12, 1993; 106(4): 1291 - 1300. [Abstract] [PDF]
|
|
