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Journal of Cell Science, Vol 103, Issue 4 1111-1116, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

Human articular surface chondrocytes initiate alkaline phosphatase and type X collagen synthesis in suspension culture

M Stephens, AP Kwan, MT Bayliss and CW Archer
Department of Orthopaedic Surgery, Institute of Orthopaedics (University College and Middlesex School of Medicine), Stanmore, UK.

The type X collagen is a short chain collagen associated with calcific cartilage and/or the expression of the hypertrophic chondrocyte phenotype. In articular cartilage, type X collagen is restricted to the basal zone of calcified cartilage adjacent to the subchondral bone. However, during pathological change such as in osteoarthritis, the synthesis of type X collagen becomes more widespread but never extends to the articular surface. Using immunocytochemistry and fluorography of newly synthesised collagens, we report that surface articular chondrocytes (which occupy the uppermost 10-15% of the tissue depth) from normal human cartilage initiate de novo synthesis of both type X collagen and alkaline phosphatase when maintained in suspension culture.
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© The Company of Biologists Ltd 1992