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Journal of Cell Science, Vol 104, Issue 1 119-123, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
A Soteriou, M Gamage and J Trinick
Department of Veterinary Medicine, Bristol University, Langford, UK.
A simple solid-phase binding assay was used to screen for interactions that the giant myofibrillar protein titin makes with other sarcomeric proteins. The titin used in the tests was purified by a modified procedure that results in isolation of approximately 20 mg relatively undegraded protein in < 24 h. In addition to the approximately 3 MDa polypeptide, bands at approximately 160 kDa and approximately 100 kDa were also consistently seen on gels. Binding of titin to myosin, C-protein, X-protein and AMP-deaminase was observed. The interaction with myosin appears to be with the light meromyosin part of the molecule.
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