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Journal of Cell Science, Vol 104, Issue 3 929-938, Copyright © 1993 by Company of Biologists

JOURNAL ARTICLES

Degradation of an extracellular matrix: sea urchin hatching enzyme removes cortical granule-derived proteins from the fertilization envelope

NM Mozingo, LR Hollar and DE Chandler
Department of Zoology, Arizona State University, Tempe 85287-1501.

The sea urchin fertilization envelope is an extracellular matrix assembled at fertilization to prevent polyspermy and protect the embryo during early development. During hatching, the embryo secretes a proteolytic hatching enzyme which dissolves the fertilization envelope, allowing a ciliated blastula to swim free. In this study we examined ultrastructural changes in the fertilization envelope during degradation of this matrix by hatching enzyme. The completed fertilization envelope is a trilaminar structure consisting of a dense, central layer of filaments sandwiched between surface coats of paracrystalline material. Hatching enzyme disassembles this matrix by degrading the paracrystalline layers and removing macromolecules from the central layer leaving behind a thin matrix of loosely woven fibers.


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J. L. Wong and G. M. Wessel
Free-radical crosslinking of specific proteins alters the function of the egg extracellular matrix at fertilization
Development, February 1, 2008; 135(3): 431 - 440.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1993