|
|
|
|
|
||
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 104, Issue 4 1021-1029, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
MD Witmer-Pack, DA Hughes, G Schuler, L Lawson, A McWilliam, K Inaba, RM Steinman and S Gordon
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021.
We used a panel of monoclonal antibodies and immunocytochemistry to identify macrophages and dendritic cells in mice that are deficient in macrophage colony stimulating factor (M-CSF or CSF-1) because of the recessive osteopetrotic (op/op) mutation. Prior work had shown that osteopetrosis is associated with a lack of osteoclasts, phagocytic cells required for remodelling in bone. Additional macrophage populations proved to be very M-CSF dependent. op/op mice had few and sometimes no peritoneal cavity phagocytes, splenic marginal zone metallophils, and lymph node subcapsular sinus macrophages. Other populations, however, reached substantial levels in the absence of M-CSF, including phagocytes in the thymic cortex, splenic red pulp, lymph node medulla, intestinal lamina propria, liver (Kupffer cells), lung (alveolar macrophages) and brain (microglia). Dendritic cells, which are specialized accessory cells for T-dependent immune responses and tolerance, were readily identified in skin and in the T-dependent regions of spleen, lymph node and Peyer's patch. The identification of dendritic cells utilized antibodies to MHC class II products and four different antigens that are primarily expressed by these accessory cells. Our findings indicate that only a few macrophage populations are critically dependent upon M-CSF in vivo. With respect to dendritic cells, the data are consistent with prior in vitro work where it was noted that GM-CSF but not M-CSF supported dendritic cell viability, function and growth.
This article has been cited by other articles:
|
|
 |
|
  J.-E. Ghia, F. Galeazzi, D. C. Ford, C. M. Hogaboam, B. A. Vallance, and S. Collins Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus Am J Physiol Gastrointest Liver Physiol, March 1, 2008; 294(3): G770 - G777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-H. Kwan, C. Boix, N. Gougelet, W. H. Fridman, and C. G. F. Mueller LPS induces rapid IL-10 release by M-CSF-conditioned tolerogenic dendritic cell precursors J. Leukoc. Biol., July 1, 2007; 82(1): 133 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Banaei-Bouchareb, M Peuchmaur, P Czernichow, and M Polak A transient microenvironment loaded mainly with macrophages in the early developing human pancreas. J. Endocrinol., March 1, 2006; 188(3): 467 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Fogg, C. Sibon, C. Miled, S. Jung, P. Aucouturier, D. R. Littman, A. Cumano, and F. Geissmann A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells Science, January 6, 2006; 311(5757): 83 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Li, Y.-J. Kim, and H. E. Broxmeyer Macrophage Colony-Stimulating Factor Drives Cord Blood Monocyte Differentiation into IL-10highIL-12absent Dendritic Cells with Tolerogenic Potential J. Immunol., April 15, 2005; 174(8): 4706 - 4717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Brown, J. Hutcheson, E. Bickel, J. C. Scatizzi, L. D. Albee, G. K. Haines III, J. Eslick, K. Bradley, E. Taricone, and H. Perlman Fas Death Receptor Signaling Represses Monocyte Numbers and Macrophage Activation In Vivo J. Immunol., December 15, 2004; 173(12): 7584 - 7593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Banaei-Bouchareb, V. Gouon-Evans, D. Samara-Boustani, M. C. Castellotti, P. Czernichow, J. W. Pollard, and M. Polak Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice J. Leukoc. Biol., August 1, 2004; 76(2): 359 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Skeen, M. M. Freeman, and H. K. Ziegler Changes in peritoneal myeloid populations and their proinflammatory cytokine expression during infection with Listeria monocytogenes are altered in the absence of {gamma}/{delta} T cells J. Leukoc. Biol., July 1, 2004; 76(1): 104 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Taylor, S. Zamze, R. J. Stillion, S. Y. C. Wong, S. Gordon, and L. Martinez-Pomares Development of a specific system for targeting protein to metallophilic macrophages PNAS, February 17, 2004; 101(7): 1963 - 1968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sato, M. Hashiguchi, E. Toda, A. Iwasaki, S. Hachimura, and S. Kaminogawa CD11b+ Peyer's Patch Dendritic Cells Secrete IL-6 and Induce IgA Secretion from Naive B Cells J. Immunol., October 1, 2003; 171(7): 3684 - 3690. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Sasmono, D. Oceandy, J. W. Pollard, W. Tong, P. Pavli, B. J. Wainwright, M. C. Ostrowski, S. R. Himes, and D. A. Hume A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse Blood, February 1, 2003; 101(3): 1155 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Cremer, M.-C. Dieu-Nosjean, S. Marechal, C. Dezutter-Dambuyant, S. Goddard, D. Adams, N. Winter, C. Menetrier-Caux, C. Sautes-Fridman, W. H. Fridman, et al. Long-lived immature dendritic cells mediated by TRANCE-RANK interaction Blood, November 15, 2002; 100(10): 3646 - 3655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Re, S. L. Belyanskaya, R. J. Riese, B. Cipriani, F. R. Fischer, F. Granucci, P. Ricciardi-Castagnoli, C. Brosnan, L. J. Stern, J. L. Strominger, et al. Granulocyte-Macrophage Colony-Stimulating Factor Induces an Expression Program in Neonatal Microglia That Primes Them for Antigen Presentation J. Immunol., September 1, 2002; 169(5): 2264 - 2273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Jin, L. Dons, K. Kristensson, and M. E. Rottenberg Colony-Stimulating Factor 1-Dependent Cells Protect against Systemic Infection with Listeria monocytogenes but Facilitate Neuroinvasion Infect. Immun., August 1, 2002; 70(8): 4682 - 4686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Oehen, B. Odermatt, U. Karrer, H. Hengartner, R. Zinkernagel, and C. Lopez-Macias Marginal Zone Macrophages and Immune Responses Against Viruses J. Immunol., August 1, 2002; 169(3): 1453 - 1458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Galeazzi, P. Lovato, P. A. Blennerhassett, E. M. Haapala, B. A. Vallance, and S. M. Collins Neural change in Trichinella-infected mice is MHC II independent and involves M-CSF-derived macrophages Am J Physiol Gastrointest Liver Physiol, July 1, 2001; 281(1): G151 - G158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Santambrogio, S. L. Belyanskaya, F. R. Fischer, B. Cipriani, C. F. Brosnan, P. Ricciardi-Castagnoli, L. J. Stern, J. L. Strominger, and R. Riese Developmental plasticity of CNS microglia PNAS, May 22, 2001; 98(11): 6295 - 6300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hemmi, M. Yoshino, H. Yamazaki, M. Naito, T. Iyoda, Y. Omatsu, S. Shimoyama, J. J. Letterio, T. Nakabayashi, H. Tagaya, et al. Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-{beta}1-dependent cells Int. Immunol., May 1, 2001; 13(5): 695 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Guleria and J. W. Pollard Aberrant Macrophage and Neutrophil Population Dynamics and Impaired Th1 Response to Listeria monocytogenes in Colony-Stimulating Factor 1-Deficient Mice Infect. Immun., March 1, 2001; 69(3): 1795 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Carenini, M. Maurer, A. Werner, H. Blazyca, K. V. Toyka, C. D. Schmid, G. Raivich, and R. Martini The Role of Macrophages in Demyelinating Peripheral Nervous System of Mice Heterozygously Deficient in P0 J. Cell Biol., January 16, 2001; 152(2): 301 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-F. Emile, F. Geissmann, O. d. l. C. Martin, I. Radford-Weiss, Y. Lepelletier, B. Heymer, T. Espanol, K. B. de Santes, Y. Bertrand, N. Brousse, et al. Langerhans cell deficiency in reticular dysgenesis Blood, July 1, 2000; 96(1): 58 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, Y. Zhang, Y. Wang, M. Ogata, S.-i. Hashimoto, N. Onai, and K. Matsushima Development of dendritic cells in vitro from murine fetal liver-derived lineage phenotype-negative c-kit+ hematopoietic progenitor cells Blood, January 1, 2000; 95(1): 138 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Sester, S. J. Beasley, M. J. Sweet, L. F. Fowles, S. L. Cronau, K. J. Stacey, and D. A. Hume Bacterial/CpG DNA Down-Modulates Colony Stimulating Factor-1 Receptor Surface Expression on Murine Bone Marrow-Derived Macrophages with Concomitant Growth Arrest and Factor-Independent Survival J. Immunol., December 15, 1999; 163(12): 6541 - 6550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, Y.-y. Zhang, M. Ogata, P. Chen, A. Harada, S.-i. Hashimoto, and K. Matsushima Transforming Growth Factor-beta 1 Polarizes Murine Hematopoietic Progenitor Cells to Generate Langerhans Cell-Like Dendritic Cells Through a Monocyte/Macrophage Differentiation Pathway Blood, February 15, 1999; 93(4): 1208 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. N. Ngo, H. Korner, M. D. Gunn, K. N. Schmidt, D. Sean Riminton, M. D. Cooper, J. L. Browning, J. D. Sedgwick, and J. G. Cyster Lymphotoxin alpha /beta and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen J. Exp. Med., January 18, 1999; 189(2): 403 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Guidez, A. C. Li, A. Horvai, J. S. Welch, and C. K. Glass Differential Utilization of Ras Signaling Pathways by Macrophage Colony-Stimulating Factor (CSF) and Granulocyte-Macrophage CSF Receptors during Macrophage Differentiation Mol. Cell. Biol., July 1, 1998; 18(7): 3851 - 3861. [Abstract] [Full Text]
|
|
|
|
|
|
P. Roth, M. G. Dominguez, and E. R. Stanley The Effects of Colony-Stimulating Factor-1 on the Distribution of Mononuclear Phagocytes in the Developing Osteopetrotic Mouse Blood, May 15, 1998; 91(10): 3773 - 3783. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. S. de Villiers, J. D. Smith, M. Miyata, H. M. Dansky, E. Darley, and S. Gordon Macrophage Phenotype in Mice Deficient in Both Macrophage-Colony–Stimulating Factor (Op) and Apolipoprotein E Arterioscler. Thromb. Vasc. Biol., April 1, 1998; 18(4): 631 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N.J. Hart Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response Blood, November 1, 1997; 90(9): 3245 - 3287. [Full Text] [PDF]
|
|
|
|
|
|
T. A. Borkowski, J. J. Letterio, A. G. Farr, and M. C. Udey A Role for Endogenous Transforming Growth Factor beta 1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor beta 1 Null Mice Is Devoid of Epidermal Langerhans Cells J. Exp. Med., December 15, 1996; 184(6): 2417 - 2422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Michaelson, P. Bieri, M. Mehler, H Xu, J. Arezzo, J. Pollard, and J. Kessler CSF-1 deficiency in mice results in abnormal brain development Development, January 9, 1996; 122(9): 2661 - 2672. [Abstract] [PDF]
|
|
|
|
|
|
M. Cecchini, M. Dominguez, S Mocci, A Wetterwald, R Felix, H Fleisch, O Chisholm, W Hofstetter, J. Pollard, and E. Stanley Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse Development, January 6, 1994; 120(6): 1357 - 1372. [Abstract] [PDF]
|
|
