|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 106, Issue 2 597-610, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
B Wehrle-Haller and M Chiquet
Department of Biophysical Chemistry, University of Basel, Switzerland.
The extracellular matrix molecule tenascin is expressed within the developing peripheral nervous system, first by migrating neural crest cells and later by satellite (Schwann precursor) cells at the growing tips of peripheral nerves. Here we found that the neurite promoting activity of tenascin for sensory neurons is developmentally regulated: very young sensory ganglia of stage 23 (4 days old) embryos grew neurites on tenascin as fast as on laminin and fibronectin. The growth response of older (day 7 and 9) ganglia on laminin and fibronectin was similar to that of 4-day-old ganglia, while on tenascin neurite growth occurred only after a lag phase and at a slower rate. Neurite growth on tenascin was inhibited by antibodies to beta 1 integrin and by heparin. While tenascin promotes neurite outgrowth of peripheral neurons, we found that it does not allow satellite cell migration when it is present on the substratum, and it inhibits migration of satellite cells on fibronectin when added in soluble form. In contrast, soluble tenascin did not significantly alter the rate of neurite growth on tenascin, fibronectin or laminin substrata, although neurites were straighter and less attached. When isolated satellite cells were added to neurites grown on tenascin, they preferentially adhered to and elongated along neurite surfaces. Using patterned substrata of tenascin versus fibronectin or laminin confirmed that tenascin borders allow neurites to pass but act as barriers to migrating satellite cells. We postulate that tenascin or related molecules with dual functions in cell adhesion are important for peripheral nerve morphogenesis. Tenascin allows axonal growth, but may restrict random satellite cell migration into the fibronectin-rich mesenchyme, thereby inducing the compaction of nerve fascicles.
This article has been cited by other articles:
|
|
 |
|
  J.-H. Jang, J.-H. Hwang, C.-P. Chung, and P.-H. Choung Identification and Kinetics Analysis of a Novel Heparin-binding Site (KEDK) in Human Tenascin-C J. Biol. Chem., June 11, 2004; 279(24): 25562 - 25566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Wenk, K. S. Midwood, and J. E. Schwarzbauer Tenascin-C Suppresses Rho Activation J. Cell Biol., August 21, 2000; 150(4): 913 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schenk, R. Chiquet-Ehrismann, and E. J. Battegay The Fibrinogen Globe of Tenascin-C Promotes Basic Fibroblast Growth Factor-induced Endothelial Cell Elongation Mol. Biol. Cell, September 1, 1999; 10(9): 2933 - 2943. [Abstract] [Full Text]
|
|
|
|
|
|
U. Zacharias, U. Norenberg, and F. G. Rathjen Functional Interactions of the Immunoglobulin Superfamily Member F11 Are Differentially Regulated by the Extracellular Matrix Proteins Tenascin-R and Tenascin-C J. Biol. Chem., August 20, 1999; 274(34): 24357 - 24365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sugawara, B.T. Himes, M. Kowada, M. Murray, A. Tessler, and W. P. Battisti Putative Inhibitory Extracellular Matrix Molecules Do Not Prevent Dorsal Root Regeneration into Fetal Spinal Cord Transplants Neurorehabil Neural Repair, June 1, 1999; 13(2): 135 - 147. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Minet, B. Rubin, R. Tucker, S Baumgartner, and R Chiquet-Ehrismann Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain J. Cell Sci., January 6, 1999; 112(12): 2019 - 2032. [Abstract] [PDF]
|
|
|
|
|
|
A. A. Spillmann, C. E. Bandtlow, F. Lottspeich, F. Keller, and M. E. Schwab Identification and Characterization of a Bovine Neurite Growth Inhibitor (bNI-220) J. Biol. Chem., July 24, 1998; 273(30): 19283 - 19293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Moscoso, H. Cremer, and J. R. Sanes Organization and Reorganization of Neuromuscular Junctions in Mice Lacking Neural Cell Adhesion Molecule, Tenascin-C, or Fibroblast Growth Factor-5 J. Neurosci., February 15, 1998; 18(4): 1465 - 1477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Phillips, L. Krushel, and K. Crossin Domains of tenascin involved in glioma migration J. Cell Sci., January 4, 1998; 111(8): 1095 - 1104. [Abstract] [PDF]
|
|
|
|
|
|
C. Neyt, M. Welch, A. Langston, J. Kohtz, and G. Fishell A Short-Range Signal Restricts Cell Movement between Telencephalic Proliferative Zones J. Neurosci., December 1, 1997; 17(23): 9194 - 9203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Fischer, M Brown-Ludi, T Schulthess, and R Chiquet-Ehrismann Concerted action of tenascin-C domains in cell adhesion, anti-adhesion and promotion of neurite outgrowth J. Cell Sci., January 7, 1997; 110(13): 1513 - 1522. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Williamson, P. R. Gordon-Weeks, M. Schachner, and J. Taylor Microtubule reorganization is obligatory for growth cone turning PNAS, December 24, 1996; 93(26): 15221 - 15226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Giese, M. Loo, S. Norman, S Treasurywala, and M. Berens Contrasting migratory response of astrocytoma cells to tenascin mediated by different integrins J. Cell Sci., January 8, 1996; 109(8): 2161 - 2168. [Abstract] [PDF]
|
|
|
|
|
|
E. Mackie and S Ramsey Modulation of osteoblast behaviour by tenascin J. Cell Sci., January 6, 1996; 109(6): 1597 - 1604. [Abstract] [PDF]
|
|
|
|
|
|
D. Fischer, R. Chiquet-Ehrismann, C. Bernasconi, and M. Chiquet A Single Heparin Binding Region within the Fibrinogen-like Domain Is Functional in Chick Tenascin-C J. Biol. Chem., February 17, 1995; 270(7): 3378 - 3384. [Abstract] [Full Text] [PDF]
|
|
