spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dauvois, S.
Right arrow Articles by Parker, M. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dauvois, S.
Right arrow Articles by Parker, M. G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal of Cell Science, Vol 106, Issue 4 1377-1388, Copyright © 1993 by Company of Biologists

JOURNAL ARTICLES

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling

S Dauvois, R White and MG Parker
Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.

The mouse estrogen receptor was shown to be constantly shuttling between the nucleus and cytoplasm although under steady-state conditions it is detected predominantly in the cell nucleus in both the absence and presence of estradiol. Shuttling was demonstrated by monitoring the transfer of protein between nuclei in heterokaryons and by examining the subcellular distribution of mutant receptors. In the presence of the partial antiestrogen 4-hydroxytamoxifen the receptor was retained in the nucleus whereas it accumulated in the cytoplasm when cells were treated with the pure antiestrogen ICI 182780. The effect of the pure antiestrogen was to inhibit nucleocytoplasmic shuttling of the receptor by blocking its nuclear uptake. Thus although ligand binding is not required by the estrogen receptor to undergo nucleocytoplasmic shuttling, this process can be disrupted by the binding of a pure antiestrogen.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Endocr Relat CancerHome page
C. Van Themsche, S. Parent, V. Leblanc, C. Descoteaux, A.-M. Simard, G. Berube, and E. Asselin
VP-128, a novel oestradiol-platinum(II) hybrid with selective anti-tumour activity towards hormone-dependent breast cancer cells in vivo
Endocr. Relat. Cancer, December 1, 2009; 16(4): 1185 - 1195.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
C. A. Oliveira, A. B. Victor-Costa, and R. A. Hess
Cellular and Regional Distributions of Ubiquitin-Proteasome and Endocytotic Pathway Components in the Epithelium of Rat Efferent Ductules and Initial Segment of the Epididymis
J Androl, September 1, 2009; 30(5): 590 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. Barone, Y. Cui, M. H. Herynk, A. Corona-Rodriguez, C. Giordano, J. Selever, A. Beyer, S. Ando, and S. A.W. Fuqua
Expression of the K303R Estrogen Receptor-{alpha} Breast Cancer Mutation Induces Resistance to an Aromatase Inhibitor via Addiction to the PI3K/Akt Kinase Pathway
Cancer Res., June 1, 2009; 69(11): 4724 - 4732.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
G. Giamas, L. Castellano, Q. Feng, U. Knippschild, J. Jacob, R. S. Thomas, R. C. Coombes, C. L. Smith, L. R. Jiao, and J. Stebbing
CK1{delta} modulates the transcriptional activity of ER{alpha} via AIB1 in an estrogen-dependent manner and regulates ER{alpha}-AIB1 interactions
Nucleic Acids Res., May 1, 2009; 37(9): 3110 - 3123.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Fan, W. Yue, J.-P. Wang, S. Aiyar, Y. Li, T.-H. Kim, and R. J. Santen
Mechanisms of Resistance to Structurally Diverse Antiestrogens Differ under Premenopausal and Postmenopausal Conditions: Evidence from in Vitro Breast Cancer Cell Models
Endocrinology, May 1, 2009; 150(5): 2036 - 2045.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
Y. Zhang, H. Zhao, S. Asztalos, M. Chisamore, Y. Sitabkhan, and D. A. Tonetti
Estradiol-Induced Regression in T47D:A18/PKC{alpha} Tumors Requires the Estrogen Receptor and Interaction with the Extracellular Matrix
Mol. Cancer Res., April 1, 2009; 7(4): 498 - 510.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. E. Ford, E. J. Ekstrom, and T. Andersson
From the Cover: Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells
PNAS, March 10, 2009; 106(10): 3919 - 3924.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. M. Fernandez, M. C. Lewis, A. S. Pechenino, L. L. Harburger, P. T. Orr, J. E. Gresack, G. E. Schafe, and K. M. Frick
Estradiol-Induced Enhancement of Object Memory Consolidation Involves Hippocampal Extracellular Signal-Regulated Kinase Activation and Membrane-Bound Estrogen Receptors
J. Neurosci., August 27, 2008; 28(35): 8660 - 8667.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Lombardi, G. Castoria, A. Migliaccio, M. V. Barone, R. Di Stasio, A. Ciociola, D. Bottero, H. Yamaguchi, E. Appella, and F. Auricchio
Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells
J. Cell Biol., July 28, 2008; 182(2): 327 - 340.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. A. Greenberg, S. Somme, H. E. Russnes, A. D. Durbin, and D. Malkin
The Estrogen Receptor Pathway in Rhabdomyosarcoma: A Role for Estrogen Receptor-{beta} in Proliferation and Response to the Antiestrogen 4'OH-Tamoxifen
Cancer Res., May 1, 2008; 68(9): 3476 - 3485.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. Chia, W. Gradishar, L. Mauriac, J. Bines, F. Amant, M. Federico, L. Fein, G. Romieu, A. Buzdar, J. F.R. Robertson, et al.
Double-Blind, Randomized Placebo Controlled Trial of Fulvestrant Compared With Exemestane After Prior Nonsteroidal Aromatase Inhibitor Therapy in Postmenopausal Women With Hormone Receptor-Positive, Advanced Breast Cancer: Results From EFECT
J. Clin. Oncol., April 1, 2008; 26(10): 1664 - 1670.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. A. Pioli, A. L. Jensen, L. K. Weaver, E. Amiel, Z. Shen, L. Shen, C. R. Wira, and P. M. Guyre
Estradiol Attenuates Lipopolysaccharide-Induced CXC Chemokine Ligand 8 Production by Human Peripheral Blood Monocytes
J. Immunol., November 1, 2007; 179(9): 6284 - 6290.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. T. Kesler, D. Gioeli, M. R. Conaway, M. J. Weber, and B. M. Paschal
Subcellular Localization Modulates Activation Function 1 Domain Phosphorylation in the Androgen Receptor
Mol. Endocrinol., September 1, 2007; 21(9): 2071 - 2084.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
D. Nonclercq, F. Journe, I. Laios, C. Chaboteaux, R.-A. Toillon, G. Leclercq, and G. Laurent
Effect of nuclear export inhibition on estrogen receptor regulation in breast cancer cells
J. Mol. Endocrinol., August 1, 2007; 39(2): 105 - 118.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. D. Wren, Y. Wu, and S.-W. Guo
A system-wide analysis of differentially expressed genes in ectopic and eutopic endometrium
Hum. Reprod., August 1, 2007; 22(8): 2093 - 2102.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
D. Gallo, E. Mantuano, M. Fabrizi, C. Ferlini, S. Mozzetti, I. De Stefano, and G. Scambia
Effects of a phytoestrogen-containing soy extract on the growth-inhibitory activity of ICI 182 780 in an experimental model of estrogen-dependent breast cancer
Endocr. Relat. Cancer, June 1, 2007; 14(2): 317 - 324.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Lupien, M. Jeyakumar, E. Hebert, K. Hilmi, D. Cotnoir-White, C. Loch, A. Auger, G. Dayan, G.-A. Pinard, J.-M. Wurtz, et al.
Raloxifene and ICI182,780 Increase Estrogen Receptor-{alpha} Association with a Nuclear Compartment via Overlapping Sets of Hydrophobic Amino Acids in Activation Function 2 Helix 12
Mol. Endocrinol., April 1, 2007; 21(4): 797 - 816.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
M. Nichols
The Fight Against Tamoxifen Resistance in Breast Cancer Therapy: A New Target in the Battle?
Mol. Interv., February 1, 2007; 7(1): 13 - 16.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Fan, J. Wang, R. J. Santen, and W. Yue
Long-term Treatment with Tamoxifen Facilitates Translocation of Estrogen Receptor {alpha} out of the Nucleus and Enhances its Interaction with EGFR in MCF-7 Breast Cancer Cells
Cancer Res., February 1, 2007; 67(3): 1352 - 1360.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
L. Zhao, K. O'Neill, and R. D. Brinton
Estrogenic Agonist Activity of ICI 182,780 (Faslodex) in Hippocampal Neurons: Implications for Basic Science Understanding of Estrogen Signaling and Development of Estrogen Modulators with a Dual Therapeutic Profile
J. Pharmacol. Exp. Ther., December 1, 2006; 319(3): 1124 - 1132.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. M. Jaber, T. Gao, L. Huang, S. Karmakar, and C. L. Smith
The Pure Estrogen Receptor Antagonist ICI 182,780 Promotes a Novel Interaction of Estrogen Receptor-{alpha} with the 3',5'-Cyclic Adenosine Monophosphate Response Element-Binding Protein-Binding Protein/p300 Coactivators
Mol. Endocrinol., November 1, 2006; 20(11): 2695 - 2710.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
A. Howell
Pure oestrogen antagonists for the treatment of advanced breast cancer.
Endocr. Relat. Cancer, September 1, 2006; 13(3): 689 - 706.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. Garcia-Pedrero, E. Kiskinis, M. G. Parker, and B. Belandia
The SWI/SNF Chromatin Remodeling Subunit BAF57 Is a Critical Regulator of Estrogen Receptor Function in Breast Cancer Cells
J. Biol. Chem., August 11, 2006; 281(32): 22656 - 22664.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
R. S. Bhattacharyya, A. V. Krishnan, S. Swami, and D. Feldman
Fulvestrant (ICI 182,780) down-regulates androgen receptor expression and diminishes androgenic responses in LNCaP human prostate cancer cells.
Mol. Cancer Ther., June 1, 2006; 5(6): 1539 - 1549.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Long and K. P. Nephew
Fulvestrant (ICI 182,780)-dependent Interacting Proteins Mediate Immobilization and Degradation of Estrogen Receptor-{alpha}
J. Biol. Chem., April 7, 2006; 281(14): 9607 - 9615.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. Lipfert, J. E. Fisher, N. Wei, A. Scafonas, Q. Su, J. Yudkovitz, F. Chen, S. Warrier, E. T. Birzin, S. Kim, et al.
Antagonist-Induced, Activation Function-2-Independent Estrogen Receptor {alpha} Phosphorylation
Mol. Endocrinol., March 1, 2006; 20(3): 516 - 533.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H.-P. Yu, M. A. Choudhry, T. Shimizu, Y.-C. Hsieh, M. G. Schwacha, S. Yang, and I. H. Chaudry
Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1
J. Leukoc. Biol., February 1, 2006; 79(2): 277 - 284.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Fan, A. Park, and K. P. Nephew
CHIP (Carboxyl Terminus of Hsc70-Interacting Protein) Promotes Basal and Geldanamycin-Induced Degradation of Estrogen Receptor-{alpha}
Mol. Endocrinol., December 1, 2005; 19(12): 2901 - 2914.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
H.-J. Kim, Y. I. Park, and M.-S. Dong
Effects of 2,4-D and DCP on the DHT-Induced Androgenic Action in Human Prostate Cancer Cells
Toxicol. Sci., November 1, 2005; 88(1): 52 - 59.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
F. F. Zheng, R.-C. Wu, C. L. Smith, and B. W. O'Malley
Rapid Estrogen-Induced Phosphorylation of the SRC-3 Coactivator Occurs in an Extranuclear Complex Containing Estrogen Receptor
Mol. Cell. Biol., September 15, 2005; 25(18): 8273 - 8284.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
K-M Rau, H-Y Kang, T-L Cha, S A Miller, and M-C Hung
The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers
Endocr. Relat. Cancer, September 1, 2005; 12(3): 511 - 532.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. F. Walther, E. Atlas, A. Carrigan, Y. Rouleau, A. Edgecombe, L. Visentin, C. Lamprecht, G. C. Addicks, R. J. G. Hache, and Y. A. Lefebvre
A Serine/Threonine-rich Motif Is One of Three Nuclear Localization Signals That Determine Unidirectional Transport of the Mineralocorticoid Receptor to the Nucleus
J. Biol. Chem., April 29, 2005; 280(17): 17549 - 17561.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
X.-F. Lin, B.-X. Zhao, H.-Z. Chen, X.-F. Ye, C.-Y. Yang, H.-Y. Zhou, M.-Q. Zhang, S.-C. Lin, and Q. Wu
RXR{alpha} acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells
J. Cell Sci., November 1, 2004; 117(23): 5609 - 5621.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. C. Whitaker, S. Hanrahan, N. Totty, S. C. Gamble, J. Waxman, A. C. B. Cato, H. C. Hurst, and C. L. Bevan
Androgen Receptor Is Targeted to Distinct Subcellular Compartments in Response to Different Therapeutic Antiandrogens
Clin. Cancer Res., November 1, 2004; 10(21): 7392 - 7401.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
P. Cheng, B. Kanterewicz, P. A. Hershberger, K. S. McCarty Jr., B. W. Day, and M. Nichols
Inhibition of Estrogen Receptor {alpha}-Mediated Transcription by Antiestrogenic 1,1-Dichloro-2,2,3-triarylcyclopropanes
Mol. Pharmacol., October 1, 2004; 66(4): 970 - 977.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. L. Smith and B. W. O'Malley
Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators
Endocr. Rev., February 1, 2004; 25(1): 45 - 71.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. M. FOWLER, N. SOLODIN, M. T. PREISLER-MASHEK, P. ZHANG, A. V. LEE, and E. T. ALARID
Increases in estrogen receptor-{alpha} concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen
FASEB J, January 1, 2004; 18(1): 81 - 93.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
C. Osipo, C. Gajdos, H. Liu, B. Chen, and V. C. Jordan
Paradoxical Action of Fulvestrant in Estradiol-Induced Regression of Tamoxifen-Stimulated Breast Cancer
J Natl Cancer Inst, November 5, 2003; 95(21): 1597 - 1608.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. F. Walther, C. Lamprecht, A. Ridsdale, I. Groulx, S. Lee, Y. A. Lefebvre, and R. J. G. Hache
Nuclear Export of the Glucocorticoid Receptor Is Accelerated by Cell Fusion-dependent Release of Calreticulin
J. Biol. Chem., September 26, 2003; 278(39): 37858 - 37864.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
M. Piccart, L. M. Parker, and K. I. Pritchard
Oestrogen receptor downregulation: an opportunity for extending the window of endocrine therapy in advanced breast cancer
Ann. Onc., July 1, 2003; 14(7): 1017 - 1025.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. M. M. Kelley, B. G. Rowan, and M. Ratnam
Modulation of the Folate Receptor {alpha} Gene by the Estrogen Receptor: Mechanism and Implications in Tumor Targeting
Cancer Res., June 1, 2003; 63(11): 2820 - 2828.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Dan, J. C. Y. Cheung, D. R. L. Scriven, and E. D. W. Moore
Epitope-dependent localization of estrogen receptoralpha , but not -beta , in en face arterial endothelium
Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1295 - H1306.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Maruvada, C. T. Baumann, G. L. Hager, and P. M. Yen
Dynamic Shuttling and Intranuclear Mobility of Nuclear Hormone Receptors
J. Biol. Chem., March 28, 2003; 278(14): 12425 - 12432.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. T. Akingbemi, R. Ge, C. S. Rosenfeld, L. G. Newton, D. O. Hardy, J. F. Catterall, D. B. Lubahn, K. S. Korach, and M. P. Hardy
Estrogen Receptor-{alpha} Gene Deficiency Enhances Androgen Biosynthesis in the Mouse Leydig Cell
Endocrinology, January 1, 2003; 144(1): 84 - 93.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Obrero, D. V. Yu, and D. J. Shapiro
Estrogen Receptor-dependent and Estrogen Receptor-independent Pathways for Tamoxifen and 4-Hydroxytamoxifen-induced Programmed Cell Death
J. Biol. Chem., November 15, 2002; 277(47): 45695 - 45703.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. Bjornstrom and M. Sjoberg
Signal Transducers and Activators of Transcription as Downstream Targets of Nongenomic Estrogen Receptor Actions
Mol. Endocrinol., October 1, 2002; 16(10): 2202 - 2214.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Lee and W. Bai
Regulation of Estrogen Receptor Nuclear Export by Ligand-Induced and p38-Mediated Receptor Phosphorylation
Mol. Cell. Biol., August 15, 2002; 22(16): 5835 - 5845.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. Prufer and J. Barsony
Retinoid X Receptor Dominates the Nuclear Import and Export of the Unliganded Vitamin D Receptor
Mol. Endocrinol., August 1, 2002; 16(8): 1738 - 1751.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
P. Yi, S. Bhagat, R. Hilf, R. A. Bambara, and M. Muyan
Differences in the Abilities of Estrogen Receptors to Integrate Activation Functions Are Critical for Subtype-Specific Transcriptional Responses
Mol. Endocrinol., August 1, 2002; 16(8): 1810 - 1827.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
A. D. Papaconstantinou, B. R. Fisher, T. H. Umbreit, P. L. Goering, N. T. Lappas, and K. M. Brown
Effects of {beta}-Estradiol and Bisphenol A on Heat Shock Protein Levels and Localization in the Mouse Uterus Are Antagonized by the Antiestrogen ICI 182,780
Toxicol. Sci., October 1, 2001; 63(2): 173 - 180.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. F. Robertson, R. I. Nicholson, N. J. Bundred, E. Anderson, Z. Rayter, M. Dowsett, J. N. Fox, J. M. W. Gee, A. Webster, A. E. Wakeling, et al.
Comparison of the Short-Term Biological Effects of 7{alpha}-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17{beta}-diol (Faslodex) versus Tamoxifen in Postmenopausal Women with Primary Breast Cancer
Cancer Res., September 1, 2001; 61(18): 6739 - 6746.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. A. Oliveira, K. Carnes, L. R. Franca, and R. A. Hess
Infertility and Testicular Atrophy in the Antiestrogen-Treated Adult Male Rat
Biol Reprod, September 1, 2001; 65(3): 913 - 920.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Pasqualini, D. Guivarc'h, J.-V. Barnier, B. Guibert, J.-D. Vincent, and P. Vernier
Differential Subcellular Distribution and Transcriptional Activity of {{Sigma}}E3, {{Sigma}}E4, and {{Sigma}}E3-4 Isoforms of the Rat Estrogen Receptor-{{alpha}}
Mol. Endocrinol., June 1, 2001; 15(6): 894 - 908.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Marcantonio, L. E. Chalifour, M. A. Alaoui-Jamali, L. Alpert, and H. T. Huynh
Cloning and Characterization of a Novel Gene That Is Regulated by Estrogen and Is Associated with Mammary Gland Carcinogenesis
Endocrinology, June 1, 2001; 142(6): 2409 - 2418.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. J. Bentrem, R. C. Dardes, H. Liu, J. MacGregor-Schafer, J. W. Zapf, and V. C. Jordan
Molecular Mechanism of Action at Estrogen Receptor {{alpha}} of a New Clinically Relevant Antiestrogen (GW7604) Related to Tamoxifen
Endocrinology, February 1, 2001; 142(2): 838 - 846.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Wan, K. K. Coxe, V. G. Thackray, P. R. Housley, and S. K. Nordeen
Separable Features of the Ligand-Binding Domain Determine the Differential Subcellular Localization and Ligand-Binding Specificity of Glucocorticoid Receptor and Progesterone Receptor
Mol. Endocrinol., January 1, 2001; 15(1): 17 - 31.
[Abstract] [Full Text]

Home page
 JCOHome page
C. K. Osborne and S. A. W. Fuqua
Selective Estrogen Receptor Modulators: Structure, Function, and Clinical Use
J. Clin. Oncol., September 17, 2000; 18(17): 3172 - 3186.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. M. Schafer, H. Liu, D. J. Bentrem, J. W. Zapf, and V. C. Jordan
Allosteric Silencing of Activating Function 1 in the 4-Hydroxytamoxifen Estrogen Receptor Complex Is Induced by Substituting Glycine for Aspartate at Amino Acid 351
Cancer Res., September 1, 2000; 60(18): 5097 - 5105.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
D. A. Schreihofer, M. H. Stoler, and M. A. Shupnik
Differential Expression and Regulation of Estrogen Receptors (ERs) in Rat Pituitary and Cell Lines: Estrogen Decreases ER{alpha} Protein and Estrogen Responsiveness
Endocrinology, June 1, 2000; 141(6): 2174 - 2184.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. de Haan, S. Chusacultanachai, C. Mao, B. S. Katzenellenbogen, and D. J. Shapiro
Estrogen Receptor-KRAB Chimeras Are Potent Ligand-dependent Repressors of Estrogen-regulated Gene Expression
J. Biol. Chem., April 28, 2000; 275(18): 13493 - 13501.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H Poukka, U Karvonen, N Yoshikawa, H Tanaka, J. Palvimo, and O. Janne
The RING finger protein SNURF modulates nuclear trafficking of the androgen receptor
J. Cell Sci., January 9, 2000; 113(17): 2991 - 3001.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
C. C. Zhang and D. J. Shapiro
Activation of the p38 Mitogen-activated Protein Kinase Pathway by Estrogen or by 4-Hydroxytamoxifen Is Coupled to Estrogen Receptor-induced Apoptosis
J. Biol. Chem., January 7, 2000; 275(1): 479 - 486.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Liu and D. B. DeFranco
Protracted Nuclear Export of Glucocorticoid Receptor Limits Its Turnover and Does Not Require the Exportin 1/CRM1-Directed Nuclear Export Pathway
Mol. Endocrinol., January 1, 2000; 14(1): 40 - 51.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
E. T. Alarid, N. Bakopoulos, and N. Solodin
Proteasome-Mediated Proteolysis of Estrogen Receptor: A Novel Component in Autologous Down-Regulation
Mol. Endocrinol., September 1, 1999; 13(9): 1522 - 1534.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
J. I. MacGregor Schafer, H. Liu, D. A. Tonetti, and V. C. Jordan
The Interaction of Raloxifene and the Active Metabolite of the Antiestrogen EM-800 (SC 5705) with the Human Estrogen Receptor
Cancer Res., September 1, 1999; 59(17): 4308 - 4313.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. D. Galigniana, P. R. Housley, D. B. DeFranco, and W. B. Pratt
Inhibition of Glucocorticoid Receptor Nucleocytoplasmic Shuttling by Okadaic Acid Requires Intact Cytoskeleton
J. Biol. Chem., June 4, 1999; 274(23): 16222 - 16227.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
W. G.R. Angus, M. C. Larsen, and C. R. Jefcoate
Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status
Carcinogenesis, June 1, 1999; 20(6): 947 - 955.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. C. Zhang, S. Krieg, and D. J. Shapiro
HMG-1 Stimulates Estrogen Response Element Binding by Estrogen Receptor from Stably Transfected HeLa Cells
Mol. Endocrinol., April 1, 1999; 13(4): 632 - 643.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
J. Liu and D. B. DeFranco
Chromatin Recycling of Glucocorticoid Receptors: Implications for Multiple Roles of Heat Shock Protein 90
Mol. Endocrinol., March 1, 1999; 13(3): 355 - 365.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
J. G. A. Savory, B. Hsu, I. R. Laquian, W. Giffin, T. Reich, R. J. G. Hache, and Y. A. Lefebvre
Discrimination between NL1- and NL2-Mediated Nuclear Localization of the Glucocorticoid Receptor
Mol. Cell. Biol., February 1, 1999; 19(2): 1025 - 1037.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
H. Htun, L. T. Holth, D. Walker, J. R. Davie, and G. L. Hager
Direct Visualization of the Human Estrogen Receptor alpha  Reveals a Role for Ligand in the Nuclear Distribution of the Receptor
Mol. Biol. Cell, February 1, 1999; 10(2): 471 - 486.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
R. J. G. Hache, R. Tse, T. Reich, J. G. A. Savory, and Y. A. Lefebvre
Nucleocytoplasmic Trafficking of Steroid-free Glucocorticoid Receptor
J. Biol. Chem., January 15, 1999; 274(3): 1432 - 1439.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Z. Nawaz, G. M. Stancel, and S. M. Hyder
The Pure Antiestrogen ICI 182,780 Inhibits Progestin-induced Transcription
Cancer Res., January 1, 1999; 59(2): 372 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. D. Galigniana, J. L. Scruggs, J. Herrington, M. J. Welsh, C. Carter-Su, P. R. Housley, and W. B. Pratt
Heat Shock Protein 90-Dependent (Geldanamycin-Inhibited) Movement of the Glucocorticoid Receptor through the Cytoplasm to the Nucleus Requires Intact Cytoskeleton
Mol. Endocrinol., December 1, 1998; 12(12): 1903 - 1913.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
R. K. Tyagi, L. Amazit, P. Lescop, E. Milgrom, and A. Guiochon-Mantel
Mechanisms of Progesterone Receptor Export from Nuclei: Role of Nuclear Localization Signal, Nuclear Export Signal, and Ran Guanosine Triphosphate
Mol. Endocrinol., November 1, 1998; 12(11): 1684 - 1695.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
S. Migliaccio, T. F. Washburn, S. Fillo, H. Rivera, A. Teti, K. S. Korach, and W. C. Wetsel
Modulation of Estrogen Receptor Levels in Mouse Uterus by Protein Kinase C Isoenzymes
Endocrinology, November 1, 1998; 139(11): 4598 - 4606.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Devin-Leclerc, X. Meng, F. Delahaye, P. Leclerc, E.-E. Baulieu, and M.-G. Catelli
Interaction and Dissociation by Ligands of Estrogen Receptor and Hsp90: The Antiestrogen RU 58668 Induces a Protein Synthesis-Dependent Clustering of the Receptor in the Cytoplasm
Mol. Endocrinol., June 1, 1998; 12(6): 842 - 854.
[Abstract] [Full Text]

Home page
 Pharmacol. Rev.Home page
J. I. Macgregor and V. C. Jordan
Basic Guide to the Mechanisms of Antiestrogen Action
Pharmacol. Rev., June 1, 1998; 50(2): 151 - 196.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
K. Yao and V. C. Jordan
Questions about Tamoxifen and the Future Use of Antiestrogens
Oncologist, April 1, 1998; 3(2): 104 - 110.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
G. F. Sewack and U. Hansen
Nucleosome Positioning and Transcription-associated Chromatin Alterations on the Human Estrogen-responsive pS2 Promoter
J. Biol. Chem., December 5, 1997; 272(49): 31118 - 31129.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Antoine, K. Reimers, C. Dickson, and P. Kiefer
Fibroblast Growth Factor 3, a Protein with Dual Subcellular Localization, Is Targeted to the Nucleus and Nucleolus by the Concerted Action of Two Nuclear Localization Signals and a Nucleolar Retention Signal
J. Biol. Chem., November 21, 1997; 272(47): 29475 - 29481.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Pace, J. Taylor, S. Suntharalingam, R. C. Coombes, and S. Ali
Human Estrogen Receptor beta  Binds DNA in a Manner Similar to and Dimerizes with Estrogen Receptor alpha
J. Biol. Chem., October 10, 1997; 272(41): 25832 - 25838.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
N. H. Bjarnason, J. Haarbo, I. Byrjalsen, R. F. Kauffman, and C. Christiansen
Raloxifene Inhibits Aortic Accumulation of Cholesterol in Ovariectomized, Cholesterol-Fed Rabbits
Circulation, September 16, 1997; 96(6): 1964 - 1969.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
T. M. Willson, J. D. Norris, B. L. Wagner, I. Asplin, P. Baer, H. R. Brown, S. A. Jones, B. Henke, H. Sauls, S. Wolfe, et al.
Dissection of the Molecular Mechanism of Action of GW5638, a Novel Estrogen Receptor Ligand, Provides Insights into the Role of Estrogen Receptor in Bone
Endocrinology, September 1, 1997; 138(9): 3901 - 3911.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
W. B. Pratt and D. O. Toft
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones
Endocr. Rev., June 1, 1997; 18(3): 306 - 360.
[Abstract] [Full Text]

Home page
 JCBHome page
J. Yang, J. Liu, and D. B. DeFranco
Subnuclear Trafficking of Glucocorticoid Receptors In Vitro: Chromatin Recycling and Nuclear Export
J. Cell Biol., May 5, 1997; 137(3): 523 - 538.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. P. Williams, H. C. Blair, M. A. McKenna, S. E. Jordan, and J. M. McDonald
Regulation of Avian Osteoclastic H[IMAGE]-ATPase and Bone Resorption by Tamoxifen and Calmodulin Antagonists
J. Biol. Chem., May 24, 1996; 271(21): 12488 - 12495.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Wang, G. A. Peters, X. Zeng, M. Tang, W. Ip, and S. A. Khan
Yeast Two-hybrid System Demonstrates That Estrogen Receptor Dimerization Is Ligand-dependent in Vivo
J. Biol. Chem., October 6, 1995; 270(40): 23322 - 23329.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. F. Su, R. Knoblauch, and M. J. Garabedian
Rho GTPases as Modulators of the Estrogen Receptor Transcriptional Response
J. Biol. Chem., January 26, 2001; 276(5): 3231 - 3237.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Gangloff, M. Ruff, S. Eiler, S. Duclaud, J. M. Wurtz, and D. Moras
Crystal Structure of a Mutant hERalpha Ligand-binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism
J. Biol. Chem., April 27, 2001; 276(18): 15059 - 15065.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. D. Galigniana, C. Radanyi, J.-M. Renoir, P. R. Housley, and W. B. Pratt
Evidence That the Peptidylprolyl Isomerase Domain of the hsp90-binding Immunophilin FKBP52 Is Involved in Both Dynein Interaction and Glucocorticoid Receptor Movement to the Nucleus
J. Biol. Chem., April 27, 2001; 276(18): 14884 - 14889.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. A. Campbell, P. Bhat-Nakshatri, N. M. Patel, D. Constantinidou, S. Ali, and H. Nakshatri
Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor alpha . A NEW MODEL FOR ANTI-ESTROGEN RESISTANCE
J. Biol. Chem., March 23, 2001; 276(13): 9817 - 9824.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. L. Wijayaratne and D. P. McDonnell
The Human Estrogen Receptor-alpha Is a Ubiquitinated Protein Whose Stability Is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators
J. Biol. Chem., September 14, 2001; 276(38): 35684 - 35692.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. W. Dudley, C. Q. Sheeler, H. Wang, and S. Khan
Activation of the human estrogen receptor by the antiestrogens ICI 182,780 and tamoxifen in yeast genetic systems: Implications for their mechanism of action
PNAS, March 28, 2000; 97(7): 3696 - 3701.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1993