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Journal of Cell Science, Vol 107, Issue 10 2779-2788, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
SL Forsburg and P Nurse
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, San Diego, CA 92186.
We have cloned and characterized the fission yeast cdc19+ gene. We demonstrate that it encodes a structural homologue of the budding yeast MCM2 protein. In fission yeast, the cdc19+ gene is constitutively expressed, and essential for viability. Deletion delays progression through S phase, and cells arrest in the first cycle with an apparent 2C DNA content, with their checkpoint control intact. The temperature-sensitive cdc19-P1 mutation is synthetically lethal with cdc21-M68. In addition, we show by classical and molecular genetics that cdc19+ is allelic to the nda1+ locus. We conclude that cdc19p plays a potentially conserved role in S phase.
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