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Journal of Cell Science, Vol 107, Issue 11 3105-3114, Copyright © 1994 by Company of Biologists

JOURNAL ARTICLES

Overexpression of a truncated cyclin B gene arrests Dictyostelium cell division during mitosis

Q Luo, C Michaelis and G Weeks
Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.

A cyclin gene has been isolated from Dictyostelium discoideum and the available evidence indicates that the gene encodes a B type cyclin. The cyclin box region of the protein encoded by the gene, clb1, has the highest degree of sequence identity with the B-type cyclins of other species. Levels of cyclin B mRNA and protein oscillate during the cell cycle with maximum accumulation of mRNA occurring prior to cell division and maximum levels of protein occurring during cell division. Overexpression of a N-terminally truncated cyclin B protein lacking the destruction box inhibits cell growth by arresting cell division during mitosis. The gene is present as a single copy in the Dictyostelium genome and there is no evidence for any other highly related cyclin B genes.


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© The Company of Biologists Ltd 1994