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Journal of Cell Science, Vol 107, Issue 12 3615-3621, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
JE Lewis, PJ Jensen, KR Johnson and MJ Wheelock
Department of Biology, University of Toledo, OH 43606.
Cultured human keratinocytes maintained in 30 microM Ca2+ do not form adherens junctions; however, when the extracellular Ca2+ concentration is raised to 1 mM, adherens junctions form very rapidly. The formation of a junction involves the coordinate organization of intracellular and extracellular components. Cadherins have been shown to mediate this coordinate organization. In this report we show that E-cadherin organizes the various junctional components by signalling through protein kinase C.
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