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Journal of Cell Science, Vol 107, Issue 12 3655-3663, Copyright © 1994 by Company of Biologists

JOURNAL ARTICLES

Assembly of the cadherin-catenin complex in vitro with recombinant proteins

H Aberle, S Butz, J Stappert, H Weissig, R Kemler and H Hoschuetzky
Max-Planck-Institut fur Immunbiologie, Freiburg, Germany.

The cytoplasmic domain of classical cadherins is tightly associated with three proteins termed alpha-, beta- and gamma-catenin. These accessory proteins are of central importance for the adhesive properties of this class of cell adhesion molecules. In order to examine the molecular architecture of the cadherin-catenin complex in more detail we have expressed the catenins and the cytoplasmic domain of E-cadherin as fusion proteins in Escherichia coli, and analyzed the interaction of purified recombinant cadherin and catenins in combinatorial protein-protein interaction experiments. The cytoplasmic domain of E-cadherin cannot directly associate with alpha-catenin but interacts with high affinity with beta-catenin, whereas the binding of gamma-catenin (plakoglobin) to E-cadherin is less efficient. alpha- and beta-catenin assemble into a 1:1 heterodimeric complex. The analysis of various truncated beta-catenins revealed that an alpha-catenin binding site in beta-catenin is localized between amino acid positions 120 and 151. The central role of beta-catenin for the assembly of the heterotrimeric E-cadherin/alpha-catenin/beta-catenin complex in mixing experiments with all components was demonstrated. The reconstitution in vitro of the cadherin-catenin complex should allow the study of the interaction with signalling molecules and with the actin-based cytoskeleton.
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S Orsulic, O Huber, H Aberle, S Arnold, and R Kemler
E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
J. Cell Sci., January 4, 1999; 112(8): 1237 - 1245.
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 DevelopmentHome page
C Bierkamp, H Schwarz, O Huber, and R Kemler
Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice
Development, January 1, 1999; 126(2): 371 - 381.
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D. D. Bannerman, M. Sathyamoorthy, and S. E. Goldblum
Bacterial Lipopolysaccharide Disrupts Endothelial Monolayer Integrity and Survival Signaling Events through Caspase Cleavage of Adherens Junction Proteins
J. Biol. Chem., December 25, 1998; 273(52): 35371 - 35380.
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 Proc. Natl. Acad. Sci. USAHome page
A. Bauer, O. Huber, and R. Kemler
Pontin52, an interaction partner of beta -catenin, binds to the TATA box binding protein
PNAS, December 8, 1998; 95(25): 14787 - 14792.
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M. Ozawa
Identification of the Region of alpha -Catenin That Plays an Essential Role in Cadherin-mediated Cell Adhesion
J. Biol. Chem., November 6, 1998; 273(45): 29524 - 29529.
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M. Ozawa and R. Kemler
The Membrane-proximal Region of the E-Cadherin Cytoplasmic Domain Prevents Dimerization and Negatively Regulates Adhesion Activity
J. Cell Biol., September 21, 1998; 142(6): 1605 - 1613.
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C. L. Adams, Y.-T. Chen, S. J Smith, and W. James Nelson
Mechanisms of Epithelial Cell-Cell Adhesion and Cell Compaction Revealed by High-resolution Tracking of E-Cadherin- Green Fluorescent Protein
J. Cell Biol., August 24, 1998; 142(4): 1105 - 1119.
[Abstract] [Full Text] [PDF]

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 Mol. Biol. CellHome page
B. Herren, B. Levkau, E. W. Raines, and R. Ross
Cleavage of beta -Catenin and Plakoglobin and Shedding of VE-Cadherin during Endothelial Apoptosis: Evidence for a Role for Caspases and Metalloproteinases
Mol. Biol. Cell, June 1, 1998; 9(6): 1589 - 1601.
[Abstract] [Full Text]

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A. S. Yap, C. M. Niessen, and B. M. Gumbiner
The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn
J. Cell Biol., May 4, 1998; 141(3): 779 - 789.
[Abstract] [Full Text] [PDF]

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E. E. Weiss, M. Kroemker, A.-H. Rudiger, B. M. Jockusch, and M. Rudiger
Vinculin Is Part of the Cadherin-Catenin Junctional Complex: Complex Formation between {alpha}-Catenin and Vinculin
J. Cell Biol., May 4, 1998; 141(3): 755 - 764.
[Abstract] [Full Text] [PDF]

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M. H. Wong, B. Rubinfeld, and J. I. Gordon
Effects of Forced Expression of an NH2-terminal Truncated {beta}-Catenin on Mouse Intestinal Epithelial Homeostasis
J. Cell Biol., May 4, 1998; 141(3): 765 - 777.
[Abstract] [Full Text] [PDF]

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J. Behrens, B. Jerchow, M. Würtele, J. Grimm, C. Asbrand, R. Wirtz, M. Kühl, D. Wedlich, and W. Birchmeier
Functional Interaction of an Axin Homolog, Conductin, with beta -Catenin, APC, and GSK3beta
Science, April 24, 1998; 280(5363): 596 - 599.
[Abstract] [Full Text]

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M. Ozawa and R. Kemler
Altered Cell Adhesion Activity by Pervanadate Due to the Dissociation of alpha -Catenin from the E-Cadherin·Catenin Complex
J. Biol. Chem., March 13, 1998; 273(11): 6166 - 6170.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
T. L. Jones, L. D. Chong, J. Kim, R.-H. Xu, H.-F. Kung, and I. O. Daar
Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand
PNAS, January 20, 1998; 95(2): 576 - 581.
[Abstract] [Full Text] [PDF]

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P. White, H. Aberle, and J.-P. Vincent
Signaling and Adhesion Activities of Mammalian {beta}-Catenin and Plakoglobin in Drosophila
J. Cell Biol., January 12, 1998; 140(1): 183 - 195.
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A. Kowalczyk, P Navarro, E Dejana, E. Bornslaeger, K. Green, D. Kopp, and J. Borgwardt
VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions
J. Cell Sci., January 10, 1998; 111(20): 3045 - 3057.
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X Pan and D. Goldfarb
YEB3/VAC8 encodes a myristylated armadillo protein of the Saccharomyces cerevisiae vacuolar membrane that functions in vacuole fusion and inheritance
J. Cell Sci., January 8, 1998; 111(15): 2137 - 2147.
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R. B. Hazan, L. Kang, S. Roe, P. I. Borgen, and D. L. Rimm
Vinculin Is Associated with the E-cadherin Adhesion Complex
J. Biol. Chem., December 19, 1997; 272(51): 32448 - 32453.
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C. Brancolini, D. Lazarevic, J. Rodriguez, and C. Schneider
Dismantling Cell-Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of {beta}-Catenin
J. Cell Biol., November 3, 1997; 139(3): 759 - 771.
[Abstract] [Full Text] [PDF]

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A. P. Kowalczyk, E. A. Bornslaeger, J. E. Borgwardt, H. L. Palka, A. S. Dhaliwal, C. M. Corcoran, M. F. Denning, and K. J. Green
The Amino-terminal Domain of Desmoplakin Binds to Plakoglobin and Clusters Desmosomal Cadherin-Plakoglobin Complexes
J. Cell Biol., November 3, 1997; 139(3): 773 - 784.
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E. R. Koslov, P. Maupin, D. Pradhan, J. S. Morrow, and D. L. Rimm
alpha -Catenin Can Form Asymmetric Homodimeric Complexes and/or Heterodimeric Complexes with beta -Catenin
J. Biol. Chem., October 24, 1997; 272(43): 27301 - 27306.
[Abstract] [Full Text] [PDF]

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M. Itoh, A. Nagafuchi, S. Moroi, and S. Tsukita
Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to {alpha} Catenin and Actin Filaments
J. Cell Biol., July 14, 1997; 138(1): 181 - 192.
[Abstract] [Full Text] [PDF]

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A. L. Pollack, A. I.M. Barth, Y. Altschuler, W. J. Nelson, and K. E. Mostov
Dynamics of {beta}-Catenin Interactions with APC Protein Regulate Epithelial Tubulogenesis
J. Cell Biol., June 30, 1997; 137(7): 1651 - 1662.
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S. Finnemann, I. Mitrik, M. Hess, G. Otto, and D. Wedlich
Uncoupling of XB/U-Cadherin-Catenin Complex Formation from Its Function in Cell-Cell Adhesion
J. Biol. Chem., May 2, 1997; 272(18): 11856 - 11862.
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H. Obama and M. Ozawa
Identification of the Domain of alpha -Catenin Involved in Its Association with beta -Catenin and Plakoglobin (gamma -Catenin)
J. Biol. Chem., April 25, 1997; 272(17): 11017 - 11020.
[Abstract] [Full Text] [PDF]

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T. Shibata, Y. Shimoyama, M. Gotoh, and S. Hirohashi
Identification of Human Cadherin-14, a Novel Neurally Specific Type II Cadherin, by Protein Interaction Cloning
J. Biol. Chem., February 21, 1997; 272(8): 5236 - 5240.
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J. Papkoff and J. Papkoff
Regulation of Complexed and Free Catenin Pools by Distinct Mechanisms. DIFFERENTIAL EFFECTS OF Wnt-1 AND v-Src
J. Biol. Chem., February 14, 1997; 272(7): 4536 - 4543.
[Abstract] [Full Text] [PDF]

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M. Torres, A. Stoykova, O. Huber, K. Chowdhury, P. Bonaldo, A. Mansouri, S. Butz, R. Kemler, and P. Gruss
An alpha -E-catenin gene trap mutation defines its function in preimplantation development
PNAS, February 4, 1997; 94(3): 901 - 906.
[Abstract] [Full Text] [PDF]


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