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Journal of Cell Science, Vol 107, Issue 12 3655-3663, Copyright © 1994 by Company of Biologists


JOURNAL ARTICLES

Assembly of the cadherin-catenin complex in vitro with recombinant proteins

H Aberle, S Butz, J Stappert, H Weissig, R Kemler and H Hoschuetzky
Max-Planck-Institut fur Immunbiologie, Freiburg, Germany.

The cytoplasmic domain of classical cadherins is tightly associated with three proteins termed alpha-, beta- and gamma-catenin. These accessory proteins are of central importance for the adhesive properties of this class of cell adhesion molecules. In order to examine the molecular architecture of the cadherin-catenin complex in more detail we have expressed the catenins and the cytoplasmic domain of E-cadherin as fusion proteins in Escherichia coli, and analyzed the interaction of purified recombinant cadherin and catenins in combinatorial protein-protein interaction experiments. The cytoplasmic domain of E-cadherin cannot directly associate with alpha-catenin but interacts with high affinity with beta-catenin, whereas the binding of gamma-catenin (plakoglobin) to E-cadherin is less efficient. alpha- and beta-catenin assemble into a 1:1 heterodimeric complex. The analysis of various truncated beta-catenins revealed that an alpha-catenin binding site in beta-catenin is localized between amino acid positions 120 and 151. The central role of beta-catenin for the assembly of the heterotrimeric E-cadherin/alpha-catenin/beta-catenin complex in mixing experiments with all components was demonstrated. The reconstitution in vitro of the cadherin-catenin complex should allow the study of the interaction with signalling molecules and with the actin-based cytoskeleton.
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J. Cell Sci., January 7, 1999; 112(14): 2265 - 2276.
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J. Cell Sci.Home page
S Orsulic, O Huber, H Aberle, S Arnold, and R Kemler
E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
J. Cell Sci., January 4, 1999; 112(8): 1237 - 1245.
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DevelopmentHome page
C Bierkamp, H Schwarz, O Huber, and R Kemler
Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice
Development, January 1, 1999; 126(2): 371 - 381.
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J. Biol. Chem.Home page
D. D. Bannerman, M. Sathyamoorthy, and S. E. Goldblum
Bacterial Lipopolysaccharide Disrupts Endothelial Monolayer Integrity and Survival Signaling Events through Caspase Cleavage of Adherens Junction Proteins
J. Biol. Chem., December 25, 1998; 273(52): 35371 - 35380.
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Proc. Natl. Acad. Sci. USAHome page
A. Bauer, O. Huber, and R. Kemler
Pontin52, an interaction partner of beta -catenin, binds to the TATA box binding protein
PNAS, December 8, 1998; 95(25): 14787 - 14792.
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J. Biol. Chem.Home page
M. Ozawa
Identification of the Region of alpha -Catenin That Plays an Essential Role in Cadherin-mediated Cell Adhesion
J. Biol. Chem., November 6, 1998; 273(45): 29524 - 29529.
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JCBHome page
M. Ozawa and R. Kemler
The Membrane-proximal Region of the E-Cadherin Cytoplasmic Domain Prevents Dimerization and Negatively Regulates Adhesion Activity
J. Cell Biol., September 21, 1998; 142(6): 1605 - 1613.
[Abstract] [Full Text] [PDF]


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JCBHome page
C. L. Adams, Y.-T. Chen, S. J Smith, and W. James Nelson
Mechanisms of Epithelial Cell-Cell Adhesion and Cell Compaction Revealed by High-resolution Tracking of E-Cadherin- Green Fluorescent Protein
J. Cell Biol., August 24, 1998; 142(4): 1105 - 1119.
[Abstract] [Full Text] [PDF]


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Mol. Biol. CellHome page
B. Herren, B. Levkau, E. W. Raines, and R. Ross
Cleavage of beta -Catenin and Plakoglobin and Shedding of VE-Cadherin during Endothelial Apoptosis: Evidence for a Role for Caspases and Metalloproteinases
Mol. Biol. Cell, June 1, 1998; 9(6): 1589 - 1601.
[Abstract] [Full Text]


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JCBHome page
A. S. Yap, C. M. Niessen, and B. M. Gumbiner
The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn
J. Cell Biol., May 4, 1998; 141(3): 779 - 789.
[Abstract] [Full Text] [PDF]


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E. E. Weiss, M. Kroemker, A.-H. Rudiger, B. M. Jockusch, and M. Rudiger
Vinculin Is Part of the Cadherin-Catenin Junctional Complex: Complex Formation between {alpha}-Catenin and Vinculin
J. Cell Biol., May 4, 1998; 141(3): 755 - 764.
[Abstract] [Full Text] [PDF]


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M. H. Wong, B. Rubinfeld, and J. I. Gordon
Effects of Forced Expression of an NH2-terminal Truncated {beta}-Catenin on Mouse Intestinal Epithelial Homeostasis
J. Cell Biol., May 4, 1998; 141(3): 765 - 777.
[Abstract] [Full Text] [PDF]


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ScienceHome page
J. Behrens, B. Jerchow, M. Würtele, J. Grimm, C. Asbrand, R. Wirtz, M. Kühl, D. Wedlich, and W. Birchmeier
Functional Interaction of an Axin Homolog, Conductin, with beta -Catenin, APC, and GSK3beta
Science, April 24, 1998; 280(5363): 596 - 599.
[Abstract] [Full Text]


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J. Biol. Chem.Home page
M. Ozawa and R. Kemler
Altered Cell Adhesion Activity by Pervanadate Due to the Dissociation of alpha -Catenin from the E-Cadherin·Catenin Complex
J. Biol. Chem., March 13, 1998; 273(11): 6166 - 6170.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
T. L. Jones, L. D. Chong, J. Kim, R.-H. Xu, H.-F. Kung, and I. O. Daar
Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand
PNAS, January 20, 1998; 95(2): 576 - 581.
[Abstract] [Full Text] [PDF]


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P. White, H. Aberle, and J.-P. Vincent
Signaling and Adhesion Activities of Mammalian {beta}-Catenin and Plakoglobin in Drosophila
J. Cell Biol., January 12, 1998; 140(1): 183 - 195.
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A. Kowalczyk, P Navarro, E Dejana, E. Bornslaeger, K. Green, D. Kopp, and J. Borgwardt
VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions
J. Cell Sci., January 10, 1998; 111(20): 3045 - 3057.
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X Pan and D. Goldfarb
YEB3/VAC8 encodes a myristylated armadillo protein of the Saccharomyces cerevisiae vacuolar membrane that functions in vacuole fusion and inheritance
J. Cell Sci., January 8, 1998; 111(15): 2137 - 2147.
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R. B. Hazan, L. Kang, S. Roe, P. I. Borgen, and D. L. Rimm
Vinculin Is Associated with the E-cadherin Adhesion Complex
J. Biol. Chem., December 19, 1997; 272(51): 32448 - 32453.
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C. Brancolini, D. Lazarevic, J. Rodriguez, and C. Schneider
Dismantling Cell-Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of {beta}-Catenin
J. Cell Biol., November 3, 1997; 139(3): 759 - 771.
[Abstract] [Full Text] [PDF]


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A. P. Kowalczyk, E. A. Bornslaeger, J. E. Borgwardt, H. L. Palka, A. S. Dhaliwal, C. M. Corcoran, M. F. Denning, and K. J. Green
The Amino-terminal Domain of Desmoplakin Binds to Plakoglobin and Clusters Desmosomal Cadherin-Plakoglobin Complexes
J. Cell Biol., November 3, 1997; 139(3): 773 - 784.
[Abstract] [Full Text] [PDF]


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E. R. Koslov, P. Maupin, D. Pradhan, J. S. Morrow, and D. L. Rimm
alpha -Catenin Can Form Asymmetric Homodimeric Complexes and/or Heterodimeric Complexes with beta -Catenin
J. Biol. Chem., October 24, 1997; 272(43): 27301 - 27306.
[Abstract] [Full Text] [PDF]


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M. Itoh, A. Nagafuchi, S. Moroi, and S. Tsukita
Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to {alpha} Catenin and Actin Filaments
J. Cell Biol., July 14, 1997; 138(1): 181 - 192.
[Abstract] [Full Text] [PDF]


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A. L. Pollack, A. I.M. Barth, Y. Altschuler, W. J. Nelson, and K. E. Mostov
Dynamics of {beta}-Catenin Interactions with APC Protein Regulate Epithelial Tubulogenesis
J. Cell Biol., June 30, 1997; 137(7): 1651 - 1662.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
S. Finnemann, I. Mitrik, M. Hess, G. Otto, and D. Wedlich
Uncoupling of XB/U-Cadherin-Catenin Complex Formation from Its Function in Cell-Cell Adhesion
J. Biol. Chem., May 2, 1997; 272(18): 11856 - 11862.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
H. Obama and M. Ozawa
Identification of the Domain of alpha -Catenin Involved in Its Association with beta -Catenin and Plakoglobin (gamma -Catenin)
J. Biol. Chem., April 25, 1997; 272(17): 11017 - 11020.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
T. Shibata, Y. Shimoyama, M. Gotoh, and S. Hirohashi
Identification of Human Cadherin-14, a Novel Neurally Specific Type II Cadherin, by Protein Interaction Cloning
J. Biol. Chem., February 21, 1997; 272(8): 5236 - 5240.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
J. Papkoff and J. Papkoff
Regulation of Complexed and Free Catenin Pools by Distinct Mechanisms. DIFFERENTIAL EFFECTS OF Wnt-1 AND v-Src
J. Biol. Chem., February 14, 1997; 272(7): 4536 - 4543.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
M. Torres, A. Stoykova, O. Huber, K. Chowdhury, P. Bonaldo, A. Mansouri, S. Butz, R. Kemler, and P. Gruss
An alpha -E-catenin gene trap mutation defines its function in preimplantation development
PNAS, February 4, 1997; 94(3): 901 - 906.
[Abstract] [Full Text] [PDF]




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