|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 107, Issue 7 1921-1928, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
K Takeuchi, A Kawashima, A Nagafuchi and S Tsukita
Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan.
Several proteins contain the domain homologous to the N-terminal half of band 4.1 protein, indicating the existence of a superfamily. The members of this 'band 4.1' superfamily are thought to play crucial roles in the regulation of cytoskeleton-plasma membrane interaction just beneath plasma membranes. We examined the structural diversity of this superfamily by means of the polymerase chain reaction using synthesized mixed primers. We thus identified many members of the band 4.1 superfamily that were expressed in mouse teratocarcinoma F9 cells and mouse brain tissue. In total, 15 cDNA clones were obtained; 8 were identical to the corresponding parts of cDNAs for the known members, while 7 appeared to encode novel proteins (NBL1-7: novel band 4.1-like proteins). Sequence analyses of these clones revealed that the band 4.1 superfamily can be subdivided into 5 gene families; band 4.1 protein, ERM (ezrin/radixin/moesin/merlin/NBL6/NBL7+ ++), talin, PTPH1 (PTPH1/PTPMEG/NBL1-3), and NBL4 (NBL4/NBL5) families. The NBL4 family was first identified here, and the full-length cDNA encoding NBL4 was cloned. The deduced amino acid sequence revealed a myristoylation site, as well as phosphorylation sites for A-kinase and tyrosine kinases in its N-terminal half, suggesting its involvement in the phosphorylation-dependent regulation of cellular events just beneath the plasma membrane. In this study, we describe the initial characterization of these new members and discuss the evolution of the band 4.1 superfamily.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. L. Whited, M. B. Robichaux, J. C. Yang, and P. A. Garrity Ptpmeg is required for the proper establishment and maintenance of axon projections in the central brain of Drosophila Development, January 1, 2007; 134(1): 43 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Komiya, M. Shimizu, J. Ikenouchi, S. Yonemura, T. Matsui, Y. Fukunaga, H. Liu, F. Endo, S. Tsukita, and A. Nagafuchi Apical membrane and junctional complex formation during simple epithelial cell differentiation of F9 cells Genes Cells, November 1, 2005; 10(11): 1065 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Fong, L. D. Burgoon, and T. R. Zacharewski Comparative Microarray Analysis of Basal Gene Expression in Mouse Hepa-1c1c7 Wild-Type and Mutant Cell Lines Toxicol. Sci., August 1, 2005; 86(2): 342 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bauer, C. Lehmann, J. Martini, F. Eckardt, and M. Hoch Gap Junction Channel Protein Innexin 2 Is Essential for Epithelial Morphogenesis in the Drosophila Embryo Mol. Biol. Cell, June 1, 2004; 15(6): 2992 - 3004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lozupone, L. Lugini, P. Matarrese, F. Luciani, C. Federici, E. Iessi, P. Margutti, G. Stassi, W. Malorni, and S. Fais Identification and Relevance of the CD95-binding Domain in the N-terminal Region of Ezrin J. Biol. Chem., March 5, 2004; 279(10): 9199 - 9207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Jobard, B. Bouadjar, F. Caux, S. Hadj-Rabia, C. Has, F. Matsuda, J. Weissenbach, M. Lathrop, J.-F. Prud'homme, and J. Fischer Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome Hum. Mol. Genet., April 15, 2003; 12(8): 925 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-X. Sun, V. A. Robb, and D. H. Gutmann Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation J. Cell Sci., November 1, 2002; 115(21): 3991 - 4000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Martín, M. J. Jasper, D. Valbuena, M. Meseguer, J. Remohí, A. Pellicer, and C. Simón Increased Adhesiveness in Cultured Endometrial-Derived Cells Is Related to the Absence of Moesin Expression Biol Reprod, November 1, 2000; 63(5): 1370 - 1376. [Abstract] [Full Text]
|
|
|
|
|
|
M. Ogata, T. Takada, Y. Mori, Y. Uchida, T. Miki, A. Okuyama, A. Kosugi, M. Sawada, M. Oh-hora, and T. Hamaoka Regulation of Phosphorylation Level and Distribution of PTP36, a Putative Protein Tyrosine Phosphatase, by Cell-Substrate Adhesion J. Biol. Chem., July 16, 1999; 274(29): 20717 - 20724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-J. C. Tang and T. K. Tang The 30-kD Domain of Protein 4.1 Mediates Its Binding to the Carboxyl Terminus of pICln, a Protein Involved in Cellular Volume Regulation Blood, August 15, 1998; 92(4): 1442 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Ward IV, R. S. Lamb, and R. G. Fehon A Conserved Functional Domain of Drosophila Coracle Is Required for Localization at the Septate Junction and Has Membrane-organizing Activity J. Cell Biol., March 23, 1998; 140(6): 1463 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yonemura, M. Hirao, Y. Doi, N. Takahashi, T. Kondo, S. Tsukita, and S. Tsukita Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2 J. Cell Biol., February 23, 1998; 140(4): 885 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsui, M. Maeda, Y. Doi, S. Yonemura, M. Amano, K. Kaibuchi, S. Tsukita, and S. Tsukita Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association J. Cell Biol., February 9, 1998; 140(3): 647 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhu, S. B. Kahwash, and L.-S. Chang Developmental Expression of Mouse Erythrocyte Protein 4.2 mRNA: Evidence for Specific Expression in Erythroid Cells Blood, January 15, 1998; 91(2): 695 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kondo, K. Takeuchi, Y. Doi, S. Yonemura, S. Nagata, S. Tsukita, and S. Tsukita ERM (Ezrin/Radixin/Moesin)-based Molecular Mechanism of Microvillar Breakdown at an Early Stage of Apoptosis J. Cell Biol., November 3, 1997; 139(3): 749 - 758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nakamura and H. Ozawa Immunolocalization of CD44 and the Ezrin-Radixin-Moesin (ERM) Family in the Stratum Intermedium and Papillary Layer of the Mouse Enamel Organ J. Histochem. Cytochem., November 1, 1997; 45(11): 1481 - 1492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Niewohner, I. Weber, M. Maniak, A. Muller-Taubenberger, and G. Gerisch Talin-Null Cells of Dictyostelium Are Strongly Defective in Adhesion to Particle and Substrate Surfaces and Slightly Impaired in Cytokinesis J. Cell Biol., July 28, 1997; 138(2): 349 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Hemmings, D. Rees, V Ohanian, S. Bolton, A. Gilmore, B Patel, H Priddle, J. Trevithick, R. Hynes, and D. Critchley Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site J. Cell Sci., January 11, 1996; 109(11): 2715 - 2726. [Abstract] [PDF]
|
|
