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Journal of Cell Science, Vol 107, Issue 8 2117-2125, Copyright © 1994 by Company of Biologists

JOURNAL ARTICLES

Changes in annexin I and II levels during the postnatal development of rat pancreatic islets

M Ohnishi, M Tokuda, T Masaki, T Fujimura, Y Tai, H Matsui, T Itano, T Ishida, J Takahara, R Konishi and al. et
Department of Physiology, Kagawa Medical School, Japan.

The expression patterns and the dynamic changes in content of both annexin I and annexin II in the rat pancreatic islets during postnatal development were investigated by both western blot analysis and immunohistochemistry. Immunohistochemical methods clearly demonstrated the presence of annexins I and II exclusively in pancreatic islets, while exocrine tissues were not stained by anti-annexin antibodies. Pancreatic islets were diffusely stained with no specific differences in distribution between different cell types. The expression of annexin I in pancreatic islets gradually increased with postnatal development. A developmental study of annexins I and II by western blot analysis essentially supported the results obtained by immunohistochemistry. In addition, the increasing expression of two protein tyrosine kinases, epidermal growth factor-receptor/kinase and pp60src, which phosphorylate annexin I and annexin II, respectively, and of protein kinase C, which phosphorylates both proteins, was also shown during postnatal development in rat pancreatic islets. Thus, a relationship between the expression of annexins I and II and the maturation of islet cell function is suggested.


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© The Company of Biologists Ltd 1994