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Journal of Cell Science, Vol 107, Issue 8 2209-2214, Copyright © 1994 by Company of Biologists

JOURNAL ARTICLES

Regulation of chemical stress-induced hsp70 gene expression in murine L929 cells

RY Liu, PM Corry and YJ Lee
Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073.

We have investigated the regulation mechanism of chemical stress-induced hsp70 gene expression in murine L929 cells. Our data show that chemical treatments including sodium arsenite, cadmium chloride and sodium salicylate, induced significant synthesis of hsp70 and its mRNA. The induced hsp70 gene expression appears to be regulated at the transcriptional level. A factor (CHBF), which constitutively binds to the heat shock element (HSE) at 37 degrees C, functions like a negative regulator and the heat-induced heat shock factor (HSF) acts as an activator. The chemical treatments that induce significant hsp70 synthesis activate HSF binding to HSE but also dissociate the HSE-CHBF complex. Some chemical treatments, e.g. IPTG, which fail to activate hsp70 gene transcription, still activate HSF binding to HSE. However, in this case, the HSE-CHBF complex remained like that of untreated control cells.
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© The Company of Biologists Ltd 1994