|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 107, Issue 9 2361-2371, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
M Cho, SM Hughes, I Karsch-Mizrachi, M Travis, LA Leinwand and HM Blau
Department of Molecular Pharmacology, Stanford University Medical Center, CA 94305-5332.
Mammalian skeletal muscle is generated by two waves of fiber formation, resulting in primary and secondary fibers. These fibers mature to give rise to several classes of adult muscle fibers with distinct contractile properties. Here we describe fast myosin heavy chain (MyHC) isoforms that are expressed in nascent secondary, but not primary, fibers in the early development of rat and human muscle. These fast MyHCs are distinct from previously described embryonic and neonatal fast MyHCs. To identify these MyHCs, monoclonal antibodies were used whose specificity was determined in western blots of MyHCs on denaturing gels and reactivity with muscle tissue at various stages of development. To facilitate a comparison of our results with those of others obtained using different antibodies or species, we have identified cDNAs that encode the epitopes recognized by our antibodies wherever possible. The results suggest that epitopes characteristic of adult fast MyHCs are expressed very early in muscle fiber development and distinguish newly formed secondary fibers from primary fibers. This marker of secondary fibers, which is detectable at the time of their inception, should prove useful in future studies of the derivation of primary and secondary fibers in mammalian muscle development.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Merrick, L. K. J. Stadler, D. Larner, and J. Smith Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation Dis. Model. Mech., July 1, 2009; 2(7-8): 374 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tajsharghi, E. Kimber, A.-K. Kroksmark, R. Jerre, M. Tulinius, and A. Oldfors Embryonic Myosin Heavy-Chain Mutations Cause Distal Arthrogryposis and Developmental Myosin Myopathy That Persists Postnatally Arch Neurol, August 1, 2008; 65(8): 1083 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Musa, S. Meek, M. Gautel, D. Peddie, A. J. H. Smith, and M. Peckham Targeted homozygous deletion of M-band titin in cardiomyocytes prevents sarcomere formation J. Cell Sci., October 15, 2006; 119(20): 4322 - 4331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. T. Swailes, M. Colegrave, P. J. Knight, and M. Peckham Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuse J. Cell Sci., September 1, 2006; 119(17): 3561 - 3570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. X Pizza, J. M Peterson, J. H Baas, and T. J Koh Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice J. Physiol., February 1, 2005; 562(3): 899 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Miller, H. Musa, M. Gautel, and M. Peckham A targeted deletion of the C-terminal end of titin, including the titin kinase domain, impairs myofibrillogenesis J. Cell Sci., December 1, 2003; 116(23): 4811 - 4819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kjellgren, L.-E. Thornell, J. Andersen, and F. Pedrosa-Domellof Myosin Heavy Chain Isoforms in Human Extraocular Muscles Invest. Ophthalmol. Vis. Sci., April 1, 2003; 44(4): 1419 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Miller, D. Thaloor, S. Matteson, and G. K. Pavlath Hepatocyte growth factor affects satellite cell activation and differentiation in regenerating skeletal muscle Am J Physiol Cell Physiol, January 1, 2000; 278(1): C174 - C181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Thaloor, K. J. Miller, J. Gephart, P. O. Mitchell, and G. K. Pavlath Systemic administration of the NF-kappa B inhibitor curcumin stimulates muscle regeneration after traumatic injury Am J Physiol Cell Physiol, August 1, 1999; 277(2): C320 - C329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Hughes, M. M.-Y. Chi, O. H. Lowry, and K. Gundersen Myogenin Induces a Shift of Enzyme Activity from Glycolytic to Oxidative Metabolism in Muscles of Transgenic Mice J. Cell Biol., May 3, 1999; 145(3): 633 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Abbott, B. B. Friday, D. Thaloor, T.J. Murphy, and G. K. Pavlath Activation and Cellular Localization of the Cyclosporine A-sensitive Transcription Factor NF-AT in Skeletal Muscle Cells Mol. Biol. Cell, October 1, 1998; 9(10): 2905 - 2916. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. S. Blagden, P. D. Currie, P. W. Ingham, and S. M. Hughes Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog Genes & Dev., September 1, 1997; 11(17): 2163 - 2175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Robson and S. Hughes The distal limb environment regulates MyoD accumulation and muscle differentiation in mouse-chick chimaeric limbs Development, January 12, 1996; 122(12): 3899 - 3910. [Abstract] [PDF]
|
|
